Cargando…
Asthma prevalence, lung and cardiovascular function in adolescents born preterm
Our main objective was to study respiratory evolution and pulmonary and cardiac function in adolescents born preterm in the post-surfactant era. Observational cross-sectional study, comparing very preterm (< 32 weeks) and moderately-late preterm adolescents (≥ 32 weeks) (74 each group). We record...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661536/ https://www.ncbi.nlm.nih.gov/pubmed/33184335 http://dx.doi.org/10.1038/s41598-020-76614-0 |
_version_ | 1783609228303269888 |
---|---|
author | Arroyas, Maria Calvo, Cristina Rueda, Santiago Esquivias, Maria Gonzalez-Menchen, Cristina Gonzalez-Carrasco, Ersilia Garcia-Garcia, Maria Luz |
author_facet | Arroyas, Maria Calvo, Cristina Rueda, Santiago Esquivias, Maria Gonzalez-Menchen, Cristina Gonzalez-Carrasco, Ersilia Garcia-Garcia, Maria Luz |
author_sort | Arroyas, Maria |
collection | PubMed |
description | Our main objective was to study respiratory evolution and pulmonary and cardiac function in adolescents born preterm in the post-surfactant era. Observational cross-sectional study, comparing very preterm (< 32 weeks) and moderately-late preterm adolescents (≥ 32 weeks) (74 each group). We recorded respiratory symptoms, spirometry and functional echocardiogram. Very preterm adolescents required more respiratory admissions (45.9% vs. 28.4%) (p = 0.03, OR 2.1, CI95% 1.1–4.2) and had more current asthma (21.6% vs. 9.5%, p = 0.04, OR 2.3, CI95% 1.1–5.2). Preterm subjects with intrauterine growth restriction (IUGR) presented lower FEV(1) (88.7 ± 13.9 vs. 95.9 ± 13.3, p = 0.027) and lower FVC (88.2 ± 13.6 vs. 95.5 ± 13.3, p = 0.025). When assessing right ventricle, very preterm showed a greater E/E’ ratio (p = 0.02) and longer myocardial performance index (MPI) (p = 0.001). Adolescents with IUGR showed less shortening fraction (p = 0.016), worse E/E′ ratio (p = 0.029) and longer MPI (p = 0.06). Regarding left ventricle, very preterm showed less E′ wave velocity (p = 0.03), greater E/E′ ratio (p = 0.005) and longer MPI (p < 0.001). Gestational age < 32 weeks is independently associated with current asthma in adolescence. Children 13–14 years old born very preterm required more respiratory admissions and had poorer diastolic and global function of both ventricles. IUGR is a risk factor for poorer lung function in preterm adolescents, regardless gestational age. |
format | Online Article Text |
id | pubmed-7661536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76615362020-11-13 Asthma prevalence, lung and cardiovascular function in adolescents born preterm Arroyas, Maria Calvo, Cristina Rueda, Santiago Esquivias, Maria Gonzalez-Menchen, Cristina Gonzalez-Carrasco, Ersilia Garcia-Garcia, Maria Luz Sci Rep Article Our main objective was to study respiratory evolution and pulmonary and cardiac function in adolescents born preterm in the post-surfactant era. Observational cross-sectional study, comparing very preterm (< 32 weeks) and moderately-late preterm adolescents (≥ 32 weeks) (74 each group). We recorded respiratory symptoms, spirometry and functional echocardiogram. Very preterm adolescents required more respiratory admissions (45.9% vs. 28.4%) (p = 0.03, OR 2.1, CI95% 1.1–4.2) and had more current asthma (21.6% vs. 9.5%, p = 0.04, OR 2.3, CI95% 1.1–5.2). Preterm subjects with intrauterine growth restriction (IUGR) presented lower FEV(1) (88.7 ± 13.9 vs. 95.9 ± 13.3, p = 0.027) and lower FVC (88.2 ± 13.6 vs. 95.5 ± 13.3, p = 0.025). When assessing right ventricle, very preterm showed a greater E/E’ ratio (p = 0.02) and longer myocardial performance index (MPI) (p = 0.001). Adolescents with IUGR showed less shortening fraction (p = 0.016), worse E/E′ ratio (p = 0.029) and longer MPI (p = 0.06). Regarding left ventricle, very preterm showed less E′ wave velocity (p = 0.03), greater E/E′ ratio (p = 0.005) and longer MPI (p < 0.001). Gestational age < 32 weeks is independently associated with current asthma in adolescence. Children 13–14 years old born very preterm required more respiratory admissions and had poorer diastolic and global function of both ventricles. IUGR is a risk factor for poorer lung function in preterm adolescents, regardless gestational age. Nature Publishing Group UK 2020-11-12 /pmc/articles/PMC7661536/ /pubmed/33184335 http://dx.doi.org/10.1038/s41598-020-76614-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Arroyas, Maria Calvo, Cristina Rueda, Santiago Esquivias, Maria Gonzalez-Menchen, Cristina Gonzalez-Carrasco, Ersilia Garcia-Garcia, Maria Luz Asthma prevalence, lung and cardiovascular function in adolescents born preterm |
title | Asthma prevalence, lung and cardiovascular function in adolescents born preterm |
title_full | Asthma prevalence, lung and cardiovascular function in adolescents born preterm |
title_fullStr | Asthma prevalence, lung and cardiovascular function in adolescents born preterm |
title_full_unstemmed | Asthma prevalence, lung and cardiovascular function in adolescents born preterm |
title_short | Asthma prevalence, lung and cardiovascular function in adolescents born preterm |
title_sort | asthma prevalence, lung and cardiovascular function in adolescents born preterm |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661536/ https://www.ncbi.nlm.nih.gov/pubmed/33184335 http://dx.doi.org/10.1038/s41598-020-76614-0 |
work_keys_str_mv | AT arroyasmaria asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm AT calvocristina asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm AT ruedasantiago asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm AT esquiviasmaria asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm AT gonzalezmenchencristina asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm AT gonzalezcarrascoersilia asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm AT garciagarciamarialuz asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm |