Cargando…

Asthma prevalence, lung and cardiovascular function in adolescents born preterm

Our main objective was to study respiratory evolution and pulmonary and cardiac function in adolescents born preterm in the post-surfactant era. Observational cross-sectional study, comparing very preterm (< 32 weeks) and moderately-late preterm adolescents (≥ 32 weeks) (74 each group). We record...

Descripción completa

Detalles Bibliográficos
Autores principales: Arroyas, Maria, Calvo, Cristina, Rueda, Santiago, Esquivias, Maria, Gonzalez-Menchen, Cristina, Gonzalez-Carrasco, Ersilia, Garcia-Garcia, Maria Luz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661536/
https://www.ncbi.nlm.nih.gov/pubmed/33184335
http://dx.doi.org/10.1038/s41598-020-76614-0
_version_ 1783609228303269888
author Arroyas, Maria
Calvo, Cristina
Rueda, Santiago
Esquivias, Maria
Gonzalez-Menchen, Cristina
Gonzalez-Carrasco, Ersilia
Garcia-Garcia, Maria Luz
author_facet Arroyas, Maria
Calvo, Cristina
Rueda, Santiago
Esquivias, Maria
Gonzalez-Menchen, Cristina
Gonzalez-Carrasco, Ersilia
Garcia-Garcia, Maria Luz
author_sort Arroyas, Maria
collection PubMed
description Our main objective was to study respiratory evolution and pulmonary and cardiac function in adolescents born preterm in the post-surfactant era. Observational cross-sectional study, comparing very preterm (< 32 weeks) and moderately-late preterm adolescents (≥ 32 weeks) (74 each group). We recorded respiratory symptoms, spirometry and functional echocardiogram. Very preterm adolescents required more respiratory admissions (45.9% vs. 28.4%) (p = 0.03, OR 2.1, CI95% 1.1–4.2) and had more current asthma (21.6% vs. 9.5%, p = 0.04, OR 2.3, CI95% 1.1–5.2). Preterm subjects with intrauterine growth restriction (IUGR) presented lower FEV(1) (88.7 ± 13.9 vs. 95.9 ± 13.3, p = 0.027) and lower FVC (88.2 ± 13.6 vs. 95.5 ± 13.3, p = 0.025). When assessing right ventricle, very preterm showed a greater E/E’ ratio (p = 0.02) and longer myocardial performance index (MPI) (p = 0.001). Adolescents with IUGR showed less shortening fraction (p = 0.016), worse E/E′ ratio (p = 0.029) and longer MPI (p = 0.06). Regarding left ventricle, very preterm showed less E′ wave velocity (p = 0.03), greater E/E′ ratio (p = 0.005) and longer MPI (p < 0.001). Gestational age < 32 weeks is independently associated with current asthma in adolescence. Children 13–14 years old born very preterm required more respiratory admissions and had poorer diastolic and global function of both ventricles. IUGR is a risk factor for poorer lung function in preterm adolescents, regardless gestational age.
format Online
Article
Text
id pubmed-7661536
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-76615362020-11-13 Asthma prevalence, lung and cardiovascular function in adolescents born preterm Arroyas, Maria Calvo, Cristina Rueda, Santiago Esquivias, Maria Gonzalez-Menchen, Cristina Gonzalez-Carrasco, Ersilia Garcia-Garcia, Maria Luz Sci Rep Article Our main objective was to study respiratory evolution and pulmonary and cardiac function in adolescents born preterm in the post-surfactant era. Observational cross-sectional study, comparing very preterm (< 32 weeks) and moderately-late preterm adolescents (≥ 32 weeks) (74 each group). We recorded respiratory symptoms, spirometry and functional echocardiogram. Very preterm adolescents required more respiratory admissions (45.9% vs. 28.4%) (p = 0.03, OR 2.1, CI95% 1.1–4.2) and had more current asthma (21.6% vs. 9.5%, p = 0.04, OR 2.3, CI95% 1.1–5.2). Preterm subjects with intrauterine growth restriction (IUGR) presented lower FEV(1) (88.7 ± 13.9 vs. 95.9 ± 13.3, p = 0.027) and lower FVC (88.2 ± 13.6 vs. 95.5 ± 13.3, p = 0.025). When assessing right ventricle, very preterm showed a greater E/E’ ratio (p = 0.02) and longer myocardial performance index (MPI) (p = 0.001). Adolescents with IUGR showed less shortening fraction (p = 0.016), worse E/E′ ratio (p = 0.029) and longer MPI (p = 0.06). Regarding left ventricle, very preterm showed less E′ wave velocity (p = 0.03), greater E/E′ ratio (p = 0.005) and longer MPI (p < 0.001). Gestational age < 32 weeks is independently associated with current asthma in adolescence. Children 13–14 years old born very preterm required more respiratory admissions and had poorer diastolic and global function of both ventricles. IUGR is a risk factor for poorer lung function in preterm adolescents, regardless gestational age. Nature Publishing Group UK 2020-11-12 /pmc/articles/PMC7661536/ /pubmed/33184335 http://dx.doi.org/10.1038/s41598-020-76614-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Arroyas, Maria
Calvo, Cristina
Rueda, Santiago
Esquivias, Maria
Gonzalez-Menchen, Cristina
Gonzalez-Carrasco, Ersilia
Garcia-Garcia, Maria Luz
Asthma prevalence, lung and cardiovascular function in adolescents born preterm
title Asthma prevalence, lung and cardiovascular function in adolescents born preterm
title_full Asthma prevalence, lung and cardiovascular function in adolescents born preterm
title_fullStr Asthma prevalence, lung and cardiovascular function in adolescents born preterm
title_full_unstemmed Asthma prevalence, lung and cardiovascular function in adolescents born preterm
title_short Asthma prevalence, lung and cardiovascular function in adolescents born preterm
title_sort asthma prevalence, lung and cardiovascular function in adolescents born preterm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661536/
https://www.ncbi.nlm.nih.gov/pubmed/33184335
http://dx.doi.org/10.1038/s41598-020-76614-0
work_keys_str_mv AT arroyasmaria asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm
AT calvocristina asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm
AT ruedasantiago asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm
AT esquiviasmaria asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm
AT gonzalezmenchencristina asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm
AT gonzalezcarrascoersilia asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm
AT garciagarciamarialuz asthmaprevalencelungandcardiovascularfunctioninadolescentsbornpreterm