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Blocking MAPK/ERK pathway sensitizes hepatocellular carcinoma cells to temozolomide via downregulating MGMT expression

BACKGROUND: Hepatocellular carcinoma (HCC) is the fourth most common malignant tumor in China. Temozolomide (TMZ) is a common chemotherapy drug which can effectively kill HCC cells in vitro. However, it is possible that HCC cells possess intrinsic resistance to TMZ. A key mechanism of TMZ resistance...

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Detalles Bibliográficos
Autores principales:	Li, Qiang, Ren, Bingjie, Gui, Qi, Zhao, Jing, Wu, Mengyao, Shen, Meng, Li, Dapeng, Li, Daoming, Chen, Kai, Tao, Min, Liang, Rongrui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661899/ https://www.ncbi.nlm.nih.gov/pubmed/33209885 http://dx.doi.org/10.21037/atm-20-5478

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