Major reduction of NKT cells in patients with severe COVID-19 pneumonia

BACKGROUND: NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. METHODS: We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healt...

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Detalles Bibliográficos
Autores principales: Zingaropoli, Maria Antonella, Perri, Valentina, Pasculli, Patrizia, Cogliati Dezza, Francesco, Nijhawan, Parni, Savelloni, Giulia, La Torre, Giuseppe, D'Agostino, Claudia, Mengoni, Fabio, Lichtner, Miriam, Ciardi, Maria Rosa, Mastroianni, Claudio Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661928/
https://www.ncbi.nlm.nih.gov/pubmed/33189887
http://dx.doi.org/10.1016/j.clim.2020.108630
Descripción
Sumario:BACKGROUND: NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. METHODS: We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. RESULTS: Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease. CONCLUSIONS: The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset.

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