Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period

Transfusion-related acute lung injury (TRALI) is a non-hemolytic adverse reaction that occurs ≤ 6 hours after receiving a transfusion. A 72-year-old man with leukemia developed severe hypoxemia after platelet transfusions on two occasions within a 4-day period. During the first episode, the transfus...

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Autores principales: Akagi, Yuina, Murata, Shogo, Yamashita, Yusuke, Tanaka, Ken, Hiroi, Takayuki, Mushino, Toshiki, Hosoi, Hiroki, Nishikawa, Akinori, Tamura, Shinobu, Sonoki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662060/
https://www.ncbi.nlm.nih.gov/pubmed/32581159
http://dx.doi.org/10.2169/internalmedicine.4700-20
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author Akagi, Yuina
Murata, Shogo
Yamashita, Yusuke
Tanaka, Ken
Hiroi, Takayuki
Mushino, Toshiki
Hosoi, Hiroki
Nishikawa, Akinori
Tamura, Shinobu
Sonoki, Takashi
author_facet Akagi, Yuina
Murata, Shogo
Yamashita, Yusuke
Tanaka, Ken
Hiroi, Takayuki
Mushino, Toshiki
Hosoi, Hiroki
Nishikawa, Akinori
Tamura, Shinobu
Sonoki, Takashi
author_sort Akagi, Yuina
collection PubMed
description Transfusion-related acute lung injury (TRALI) is a non-hemolytic adverse reaction that occurs ≤ 6 hours after receiving a transfusion. A 72-year-old man with leukemia developed severe hypoxemia after platelet transfusions on two occasions within a 4-day period. During the first episode, the transfused platelet preparation was positive for anti-human-leukocyte antigen antibodies. The pathogenesis of TRALI includes an antibody-mediated mechanism and a non-antibody-mediated mechanism, in which various factors combine to activate pulmonary neutrophils. In our case, it is considered that the patient's neutrophils reached the activation threshold for the development of TRALI after the accumulation of various factors besides anti-leukocyte antibodies.
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spelling pubmed-76620602020-11-25 Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period Akagi, Yuina Murata, Shogo Yamashita, Yusuke Tanaka, Ken Hiroi, Takayuki Mushino, Toshiki Hosoi, Hiroki Nishikawa, Akinori Tamura, Shinobu Sonoki, Takashi Intern Med Case Report Transfusion-related acute lung injury (TRALI) is a non-hemolytic adverse reaction that occurs ≤ 6 hours after receiving a transfusion. A 72-year-old man with leukemia developed severe hypoxemia after platelet transfusions on two occasions within a 4-day period. During the first episode, the transfused platelet preparation was positive for anti-human-leukocyte antigen antibodies. The pathogenesis of TRALI includes an antibody-mediated mechanism and a non-antibody-mediated mechanism, in which various factors combine to activate pulmonary neutrophils. In our case, it is considered that the patient's neutrophils reached the activation threshold for the development of TRALI after the accumulation of various factors besides anti-leukocyte antibodies. The Japanese Society of Internal Medicine 2020-06-23 2020-10-15 /pmc/articles/PMC7662060/ /pubmed/32581159 http://dx.doi.org/10.2169/internalmedicine.4700-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Akagi, Yuina
Murata, Shogo
Yamashita, Yusuke
Tanaka, Ken
Hiroi, Takayuki
Mushino, Toshiki
Hosoi, Hiroki
Nishikawa, Akinori
Tamura, Shinobu
Sonoki, Takashi
Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period
title Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period
title_full Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period
title_fullStr Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period
title_full_unstemmed Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period
title_short Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period
title_sort two episodes of transfusion-related acute lung injury (trali) occurring within a short period
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662060/
https://www.ncbi.nlm.nih.gov/pubmed/32581159
http://dx.doi.org/10.2169/internalmedicine.4700-20
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