Cargando…
Transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in COVID-19 syndrome
Despite the devastating impact of COVID-19 on all domains of health, very few studies focus on epigenetics-based approaches to target both the viral-host immune responses and central nervous system involvement in COVID-19. Hospitalized COVID-19 patients experience a wide array of neurological sympto...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662068/ http://dx.doi.org/10.1016/B978-0-12-820593-8.00018-5 |
_version_ | 1783609322652041216 |
---|---|
author | Chiu, Simon S. Terpstra, Kristen Woodbury-Farina, Michel Badmaev, Vladimir Varghese, Josh Raheb, Hana Lui, Ed Cernovsky, Zack Bureau, Yves Husni, Mariwan Copen, John Shad, Mujeeb Carriere, Autumn Khazaeipool, Zahra Sieffien, Weam Henein, Marina Casola, Brendan Shrivastava, Siddhansh |
author_facet | Chiu, Simon S. Terpstra, Kristen Woodbury-Farina, Michel Badmaev, Vladimir Varghese, Josh Raheb, Hana Lui, Ed Cernovsky, Zack Bureau, Yves Husni, Mariwan Copen, John Shad, Mujeeb Carriere, Autumn Khazaeipool, Zahra Sieffien, Weam Henein, Marina Casola, Brendan Shrivastava, Siddhansh |
author_sort | Chiu, Simon S. |
collection | PubMed |
description | Despite the devastating impact of COVID-19 on all domains of health, very few studies focus on epigenetics-based approaches to target both the viral-host immune responses and central nervous system involvement in COVID-19. Hospitalized COVID-19 patients experience a wide array of neurological symptoms ranging from convulsions to strokelike syndrome and anosmia. None of the pipeline antiviral drugs has been shown to penetrate the blood-brain barrier to exert neurotrophic actions to counteract the COVID-19 damage to the brain. We have identified curcumin extracted from Turmeric (Curcuma longa) exhibiting dual properties: to disrupt viral attachment and hijacking host-viral immune response and to target epigenetics pathway regulating oxidative stress and inflammation responses underlying COVID-19 syndrome. We recruit nanotechnology to formulate liposome-based curcumin: Lipocurc, and completed Phase I study showing very favorable safety and efficacy in Parkinson disease model. We propose to translate the findings to COVID-19 syndrome and exploit the antidepressant and cognitive enhancing properties to accelerate recovery from COVID-19 through navigating brain pathways regulating mood, behavioral control, and cognition within the context of acute and postacute COVID-19 syndrome. |
format | Online Article Text |
id | pubmed-7662068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-76620682020-11-13 Transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in COVID-19 syndrome Chiu, Simon S. Terpstra, Kristen Woodbury-Farina, Michel Badmaev, Vladimir Varghese, Josh Raheb, Hana Lui, Ed Cernovsky, Zack Bureau, Yves Husni, Mariwan Copen, John Shad, Mujeeb Carriere, Autumn Khazaeipool, Zahra Sieffien, Weam Henein, Marina Casola, Brendan Shrivastava, Siddhansh Nutraceuticals in Brain Health and Beyond Article Despite the devastating impact of COVID-19 on all domains of health, very few studies focus on epigenetics-based approaches to target both the viral-host immune responses and central nervous system involvement in COVID-19. Hospitalized COVID-19 patients experience a wide array of neurological symptoms ranging from convulsions to strokelike syndrome and anosmia. None of the pipeline antiviral drugs has been shown to penetrate the blood-brain barrier to exert neurotrophic actions to counteract the COVID-19 damage to the brain. We have identified curcumin extracted from Turmeric (Curcuma longa) exhibiting dual properties: to disrupt viral attachment and hijacking host-viral immune response and to target epigenetics pathway regulating oxidative stress and inflammation responses underlying COVID-19 syndrome. We recruit nanotechnology to formulate liposome-based curcumin: Lipocurc, and completed Phase I study showing very favorable safety and efficacy in Parkinson disease model. We propose to translate the findings to COVID-19 syndrome and exploit the antidepressant and cognitive enhancing properties to accelerate recovery from COVID-19 through navigating brain pathways regulating mood, behavioral control, and cognition within the context of acute and postacute COVID-19 syndrome. 2021 2020-11-13 /pmc/articles/PMC7662068/ http://dx.doi.org/10.1016/B978-0-12-820593-8.00018-5 Text en Copyright © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Chiu, Simon S. Terpstra, Kristen Woodbury-Farina, Michel Badmaev, Vladimir Varghese, Josh Raheb, Hana Lui, Ed Cernovsky, Zack Bureau, Yves Husni, Mariwan Copen, John Shad, Mujeeb Carriere, Autumn Khazaeipool, Zahra Sieffien, Weam Henein, Marina Casola, Brendan Shrivastava, Siddhansh Transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in COVID-19 syndrome |
title | Transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in COVID-19 syndrome |
title_full | Transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in COVID-19 syndrome |
title_fullStr | Transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in COVID-19 syndrome |
title_full_unstemmed | Transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in COVID-19 syndrome |
title_short | Transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in COVID-19 syndrome |
title_sort | transforming curry extract-spice to liposome-based curcumin: lipocurc to restore and boost brain health in covid-19 syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662068/ http://dx.doi.org/10.1016/B978-0-12-820593-8.00018-5 |
work_keys_str_mv | AT chiusimons transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT terpstrakristen transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT woodburyfarinamichel transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT badmaevvladimir transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT varghesejosh transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT rahebhana transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT luied transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT cernovskyzack transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT bureauyves transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT husnimariwan transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT copenjohn transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT shadmujeeb transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT carriereautumn transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT khazaeipoolzahra transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT sieffienweam transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT heneinmarina transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT casolabrendan transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome AT shrivastavasiddhansh transformingcurryextractspicetoliposomebasedcurcuminlipocurctorestoreandboostbrainhealthincovid19syndrome |