LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway

Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism...

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Autores principales: Li, Hu, Zeng, Zheng, Yang, Xiang, Chen, Ye, He, Lei, Wan, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662106/
https://www.ncbi.nlm.nih.gov/pubmed/33207861
http://dx.doi.org/10.4081/ejh.2020.3166
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author Li, Hu
Zeng, Zheng
Yang, Xiang
Chen, Ye
He, Lei
Wan, Ting
author_facet Li, Hu
Zeng, Zheng
Yang, Xiang
Chen, Ye
He, Lei
Wan, Ting
author_sort Li, Hu
collection PubMed
description Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.
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spelling pubmed-76621062020-11-17 LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway Li, Hu Zeng, Zheng Yang, Xiang Chen, Ye He, Lei Wan, Ting Eur J Histochem Brief Report Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients. PAGEPress Publications, Pavia, Italy 2020-11-10 /pmc/articles/PMC7662106/ /pubmed/33207861 http://dx.doi.org/10.4081/ejh.2020.3166 Text en ©Copyright: the Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Li, Hu
Zeng, Zheng
Yang, Xiang
Chen, Ye
He, Lei
Wan, Ting
LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
title LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
title_full LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
title_fullStr LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
title_full_unstemmed LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
title_short LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
title_sort lncrna gclnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662106/
https://www.ncbi.nlm.nih.gov/pubmed/33207861
http://dx.doi.org/10.4081/ejh.2020.3166
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