In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms

BACKGROUND: Rifabutin, an oral drug approved to treat Mycobacterium avium infections, demonstrated potent activity against Acinetobacter baumannii in nutrient-limited medium enabled by rifabutin cellular uptake through the siderophore receptor FhuE. OBJECTIVES: To determine rifabutin in vitro activi...

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Detalles Bibliográficos
Autores principales: Trebosc, Vincent, Schellhorn, Birgit, Schill, Julian, Lucchini, Valentina, Bühler, Jacqueline, Bourotte, Marilyne, Butcher, Jonathan J, Gitzinger, Marc, Lociuro, Sergio, Kemmer, Christian, Dale, Glenn E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662187/
https://www.ncbi.nlm.nih.gov/pubmed/32869081
http://dx.doi.org/10.1093/jac/dkaa370

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