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Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu- and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology

We report a case of an uveal melanoma patient with GNAQ p.Gly48Leu who responded to MEK inhibition. At the time of the molecular analysis, the pathogenicity of the mutation was unknown. A tridimensional structural analysis showed that Gα(q) can adopt active and inactive conformations that lead to su...

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Detalles Bibliográficos
Autores principales:	Krebs, Fanny S., Gérard, Camille, Wicky, Alexandre, Aedo-Lopez, Veronica, Missiaglia, Edoardo, Bisig, Bettina, Trimech, Mounir, Michielin, Olivier, Homicsko, Krisztian, Zoete, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662249/ https://www.ncbi.nlm.nih.gov/pubmed/33126538 http://dx.doi.org/10.3390/ijms21218021

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