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Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53

Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of DMP1, ARF, and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the...

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Autores principales: Fry, Elizabeth A., Niehans, Gloria E., Kratzke, Robert A., Kai, Fumitake, Inoue, Kazushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662351/
https://www.ncbi.nlm.nih.gov/pubmed/33120969
http://dx.doi.org/10.3390/ijms21217971
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author Fry, Elizabeth A.
Niehans, Gloria E.
Kratzke, Robert A.
Kai, Fumitake
Inoue, Kazushi
author_facet Fry, Elizabeth A.
Niehans, Gloria E.
Kratzke, Robert A.
Kai, Fumitake
Inoue, Kazushi
author_sort Fry, Elizabeth A.
collection PubMed
description Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of DMP1, ARF, and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the University of Minnesota VA hospital and those from the Wake Forest University Hospital. Loss of Heterozygosity (LOH) for hDMP1 was found in 26 of 70 cases (37.1%), that of the ARF/INK4a locus was found in 33 of 70 (47.1%), and that of the p53 locus in 43 cases (61.4%) in the University of Minnesota samples. LOH for hDMP1 was associated with favorable prognosis while that of p53 predicted worse prognosis. The survival was much shorter for ARF-loss than INK4a-loss, emphasizing the importance of ARF in human NSCLC. The adverse effect of p53 LOH on NSCLC patients’ survival was neutralized by simultaneous loss of the hDMP1 locus in NSCLC and breast cancer, suggesting the possible therapy of epithelial cancers with metastatic ability.
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spelling pubmed-76623512020-11-14 Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53 Fry, Elizabeth A. Niehans, Gloria E. Kratzke, Robert A. Kai, Fumitake Inoue, Kazushi Int J Mol Sci Article Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of DMP1, ARF, and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the University of Minnesota VA hospital and those from the Wake Forest University Hospital. Loss of Heterozygosity (LOH) for hDMP1 was found in 26 of 70 cases (37.1%), that of the ARF/INK4a locus was found in 33 of 70 (47.1%), and that of the p53 locus in 43 cases (61.4%) in the University of Minnesota samples. LOH for hDMP1 was associated with favorable prognosis while that of p53 predicted worse prognosis. The survival was much shorter for ARF-loss than INK4a-loss, emphasizing the importance of ARF in human NSCLC. The adverse effect of p53 LOH on NSCLC patients’ survival was neutralized by simultaneous loss of the hDMP1 locus in NSCLC and breast cancer, suggesting the possible therapy of epithelial cancers with metastatic ability. MDPI 2020-10-27 /pmc/articles/PMC7662351/ /pubmed/33120969 http://dx.doi.org/10.3390/ijms21217971 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fry, Elizabeth A.
Niehans, Gloria E.
Kratzke, Robert A.
Kai, Fumitake
Inoue, Kazushi
Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53
title Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53
title_full Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53
title_fullStr Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53
title_full_unstemmed Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53
title_short Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53
title_sort survival of lung cancer patients dependent on the loh status for dmp1, arf, and p53
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662351/
https://www.ncbi.nlm.nih.gov/pubmed/33120969
http://dx.doi.org/10.3390/ijms21217971
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