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Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53
Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of DMP1, ARF, and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662351/ https://www.ncbi.nlm.nih.gov/pubmed/33120969 http://dx.doi.org/10.3390/ijms21217971 |
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author | Fry, Elizabeth A. Niehans, Gloria E. Kratzke, Robert A. Kai, Fumitake Inoue, Kazushi |
author_facet | Fry, Elizabeth A. Niehans, Gloria E. Kratzke, Robert A. Kai, Fumitake Inoue, Kazushi |
author_sort | Fry, Elizabeth A. |
collection | PubMed |
description | Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of DMP1, ARF, and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the University of Minnesota VA hospital and those from the Wake Forest University Hospital. Loss of Heterozygosity (LOH) for hDMP1 was found in 26 of 70 cases (37.1%), that of the ARF/INK4a locus was found in 33 of 70 (47.1%), and that of the p53 locus in 43 cases (61.4%) in the University of Minnesota samples. LOH for hDMP1 was associated with favorable prognosis while that of p53 predicted worse prognosis. The survival was much shorter for ARF-loss than INK4a-loss, emphasizing the importance of ARF in human NSCLC. The adverse effect of p53 LOH on NSCLC patients’ survival was neutralized by simultaneous loss of the hDMP1 locus in NSCLC and breast cancer, suggesting the possible therapy of epithelial cancers with metastatic ability. |
format | Online Article Text |
id | pubmed-7662351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76623512020-11-14 Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53 Fry, Elizabeth A. Niehans, Gloria E. Kratzke, Robert A. Kai, Fumitake Inoue, Kazushi Int J Mol Sci Article Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of DMP1, ARF, and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the University of Minnesota VA hospital and those from the Wake Forest University Hospital. Loss of Heterozygosity (LOH) for hDMP1 was found in 26 of 70 cases (37.1%), that of the ARF/INK4a locus was found in 33 of 70 (47.1%), and that of the p53 locus in 43 cases (61.4%) in the University of Minnesota samples. LOH for hDMP1 was associated with favorable prognosis while that of p53 predicted worse prognosis. The survival was much shorter for ARF-loss than INK4a-loss, emphasizing the importance of ARF in human NSCLC. The adverse effect of p53 LOH on NSCLC patients’ survival was neutralized by simultaneous loss of the hDMP1 locus in NSCLC and breast cancer, suggesting the possible therapy of epithelial cancers with metastatic ability. MDPI 2020-10-27 /pmc/articles/PMC7662351/ /pubmed/33120969 http://dx.doi.org/10.3390/ijms21217971 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fry, Elizabeth A. Niehans, Gloria E. Kratzke, Robert A. Kai, Fumitake Inoue, Kazushi Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53 |
title | Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53 |
title_full | Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53 |
title_fullStr | Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53 |
title_full_unstemmed | Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53 |
title_short | Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53 |
title_sort | survival of lung cancer patients dependent on the loh status for dmp1, arf, and p53 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662351/ https://www.ncbi.nlm.nih.gov/pubmed/33120969 http://dx.doi.org/10.3390/ijms21217971 |
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