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Impact of Gene–Environment Interactions on Cancer Development

Several epidemiological and experimental studies have demonstrated that many human diseases are not only caused by specific genetic and environmental factors but also by gene–environment interactions. Although it has been widely reported that genetic polymorphisms play a critical role in human susce...

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Autores principales: Mbemi, Ariane, Khanna, Sunali, Njiki, Sylvianne, Yedjou, Clement G., Tchounwou, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662361/
https://www.ncbi.nlm.nih.gov/pubmed/33153024
http://dx.doi.org/10.3390/ijerph17218089
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author Mbemi, Ariane
Khanna, Sunali
Njiki, Sylvianne
Yedjou, Clement G.
Tchounwou, Paul B.
author_facet Mbemi, Ariane
Khanna, Sunali
Njiki, Sylvianne
Yedjou, Clement G.
Tchounwou, Paul B.
author_sort Mbemi, Ariane
collection PubMed
description Several epidemiological and experimental studies have demonstrated that many human diseases are not only caused by specific genetic and environmental factors but also by gene–environment interactions. Although it has been widely reported that genetic polymorphisms play a critical role in human susceptibility to cancer and other chronic disease conditions, many single nucleotide polymorphisms (SNPs) are caused by somatic mutations resulting from human exposure to environmental stressors. Scientific evidence suggests that the etiology of many chronic illnesses is caused by the joint effect between genetics and the environment. Research has also pointed out that the interactions of environmental factors with specific allelic variants highly modulate the susceptibility to diseases. Hence, many scientific discoveries on gene–environment interactions have elucidated the impact of their combined effect on the incidence and/or prevalence rate of human diseases. In this review, we provide an overview of the nature of gene–environment interactions, and discuss their role in human cancers, with special emphases on lung, colorectal, bladder, breast, ovarian, and prostate cancers.
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spelling pubmed-76623612020-11-14 Impact of Gene–Environment Interactions on Cancer Development Mbemi, Ariane Khanna, Sunali Njiki, Sylvianne Yedjou, Clement G. Tchounwou, Paul B. Int J Environ Res Public Health Review Several epidemiological and experimental studies have demonstrated that many human diseases are not only caused by specific genetic and environmental factors but also by gene–environment interactions. Although it has been widely reported that genetic polymorphisms play a critical role in human susceptibility to cancer and other chronic disease conditions, many single nucleotide polymorphisms (SNPs) are caused by somatic mutations resulting from human exposure to environmental stressors. Scientific evidence suggests that the etiology of many chronic illnesses is caused by the joint effect between genetics and the environment. Research has also pointed out that the interactions of environmental factors with specific allelic variants highly modulate the susceptibility to diseases. Hence, many scientific discoveries on gene–environment interactions have elucidated the impact of their combined effect on the incidence and/or prevalence rate of human diseases. In this review, we provide an overview of the nature of gene–environment interactions, and discuss their role in human cancers, with special emphases on lung, colorectal, bladder, breast, ovarian, and prostate cancers. MDPI 2020-11-03 2020-11 /pmc/articles/PMC7662361/ /pubmed/33153024 http://dx.doi.org/10.3390/ijerph17218089 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mbemi, Ariane
Khanna, Sunali
Njiki, Sylvianne
Yedjou, Clement G.
Tchounwou, Paul B.
Impact of Gene–Environment Interactions on Cancer Development
title Impact of Gene–Environment Interactions on Cancer Development
title_full Impact of Gene–Environment Interactions on Cancer Development
title_fullStr Impact of Gene–Environment Interactions on Cancer Development
title_full_unstemmed Impact of Gene–Environment Interactions on Cancer Development
title_short Impact of Gene–Environment Interactions on Cancer Development
title_sort impact of gene–environment interactions on cancer development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662361/
https://www.ncbi.nlm.nih.gov/pubmed/33153024
http://dx.doi.org/10.3390/ijerph17218089
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