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Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly...

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Autores principales: Watts, Deepika, Gaete, Diana, Rodriguez, Diego, Hoogewijs, David, Rauner, Martina, Sormendi, Sundary, Wielockx, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662373/
https://www.ncbi.nlm.nih.gov/pubmed/33143240
http://dx.doi.org/10.3390/ijms21218131
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author Watts, Deepika
Gaete, Diana
Rodriguez, Diego
Hoogewijs, David
Rauner, Martina
Sormendi, Sundary
Wielockx, Ben
author_facet Watts, Deepika
Gaete, Diana
Rodriguez, Diego
Hoogewijs, David
Rauner, Martina
Sormendi, Sundary
Wielockx, Ben
author_sort Watts, Deepika
collection PubMed
description Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO(2)) as under-deprived oxygen (hypoxia); the transcription factor hypoxia-inducible factor-2 induces EPO. However, erythropoiesis regulation extends beyond the well-established hypoxia-inducible factor (HIF)–EPO axis and involves processes modulated by other hypoxia pathway proteins (HPPs), including proteins involved in iron metabolism. The importance of a number of these factors is evident as their altered expression has been associated with various anemia-related disorders, including chronic kidney disease. Eventually, our emerging understanding of HPPs and their regulatory feedback will be instrumental in developing specific therapies for anemic patients and beyond.
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spelling pubmed-76623732020-11-14 Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis Watts, Deepika Gaete, Diana Rodriguez, Diego Hoogewijs, David Rauner, Martina Sormendi, Sundary Wielockx, Ben Int J Mol Sci Review Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO(2)) as under-deprived oxygen (hypoxia); the transcription factor hypoxia-inducible factor-2 induces EPO. However, erythropoiesis regulation extends beyond the well-established hypoxia-inducible factor (HIF)–EPO axis and involves processes modulated by other hypoxia pathway proteins (HPPs), including proteins involved in iron metabolism. The importance of a number of these factors is evident as their altered expression has been associated with various anemia-related disorders, including chronic kidney disease. Eventually, our emerging understanding of HPPs and their regulatory feedback will be instrumental in developing specific therapies for anemic patients and beyond. MDPI 2020-10-30 /pmc/articles/PMC7662373/ /pubmed/33143240 http://dx.doi.org/10.3390/ijms21218131 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Watts, Deepika
Gaete, Diana
Rodriguez, Diego
Hoogewijs, David
Rauner, Martina
Sormendi, Sundary
Wielockx, Ben
Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis
title Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis
title_full Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis
title_fullStr Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis
title_full_unstemmed Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis
title_short Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis
title_sort hypoxia pathway proteins are master regulators of erythropoiesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662373/
https://www.ncbi.nlm.nih.gov/pubmed/33143240
http://dx.doi.org/10.3390/ijms21218131
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