New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity

Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (3–9). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosi...

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Autores principales: Thant, May Thazin, Chatsumpun, Nutputsorn, Mekboonsonglarp, Wanwimon, Sritularak, Boonchoo, Likhitwitayawuid, Kittisak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662385/
https://www.ncbi.nlm.nih.gov/pubmed/33113779
http://dx.doi.org/10.3390/molecules25214931
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author Thant, May Thazin
Chatsumpun, Nutputsorn
Mekboonsonglarp, Wanwimon
Sritularak, Boonchoo
Likhitwitayawuid, Kittisak
author_facet Thant, May Thazin
Chatsumpun, Nutputsorn
Mekboonsonglarp, Wanwimon
Sritularak, Boonchoo
Likhitwitayawuid, Kittisak
author_sort Thant, May Thazin
collection PubMed
description Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (3–9). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities. Dendrogibsol (2) and lusianthridin (7) showed strong α-glucosidase inhibitory activity when compared with acarbose. An enzyme kinetic study revealed that dendrogibsol (2) is a noncompetitive inhibitor of α-glucosidase.
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spelling pubmed-76623852020-11-14 New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity Thant, May Thazin Chatsumpun, Nutputsorn Mekboonsonglarp, Wanwimon Sritularak, Boonchoo Likhitwitayawuid, Kittisak Molecules Article Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (3–9). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities. Dendrogibsol (2) and lusianthridin (7) showed strong α-glucosidase inhibitory activity when compared with acarbose. An enzyme kinetic study revealed that dendrogibsol (2) is a noncompetitive inhibitor of α-glucosidase. MDPI 2020-10-25 /pmc/articles/PMC7662385/ /pubmed/33113779 http://dx.doi.org/10.3390/molecules25214931 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thant, May Thazin
Chatsumpun, Nutputsorn
Mekboonsonglarp, Wanwimon
Sritularak, Boonchoo
Likhitwitayawuid, Kittisak
New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
title New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
title_full New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
title_fullStr New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
title_full_unstemmed New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
title_short New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
title_sort new fluorene derivatives from dendrobium gibsonii and their α-glucosidase inhibitory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662385/
https://www.ncbi.nlm.nih.gov/pubmed/33113779
http://dx.doi.org/10.3390/molecules25214931
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