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Timing of the Sense of Volition in Patients With Schizophrenia

Schizophrenic patients often do not have the sense that they direct their own movements or author their own thoughts (passivity phenomena). As willing must precede movement to be causal and thus generate the sense of agency, it is possible that the timing between the senses of willing and movement i...

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Autores principales: Pirio Richardson, Sarah, Triggiani, Antonio I., Matsuhashi, Masao, Voon, Valerie, Peckham, Elizabeth, Nahab, Fatta, Mari, Zoltan, Hallett, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662453/
https://www.ncbi.nlm.nih.gov/pubmed/33192259
http://dx.doi.org/10.3389/fnins.2020.574472
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author Pirio Richardson, Sarah
Triggiani, Antonio I.
Matsuhashi, Masao
Voon, Valerie
Peckham, Elizabeth
Nahab, Fatta
Mari, Zoltan
Hallett, Mark
author_facet Pirio Richardson, Sarah
Triggiani, Antonio I.
Matsuhashi, Masao
Voon, Valerie
Peckham, Elizabeth
Nahab, Fatta
Mari, Zoltan
Hallett, Mark
author_sort Pirio Richardson, Sarah
collection PubMed
description Schizophrenic patients often do not have the sense that they direct their own movements or author their own thoughts (passivity phenomena). As willing must precede movement to be causal and thus generate the sense of agency, it is possible that the timing between the senses of willing and movement is shortened in schizophrenia. We tested the subjective perception of this time interval in patients with schizophrenia using a method based on Libet’s paradigm, in which subjects specify a time W – the time of willing a movement – and a time M – the time that movement occurred. Patients with schizophrenia and healthy volunteers made voluntary movements at times of their own choice while looking at a fast-rotating clock on a computer screen and reported when their movements were willed and made. We recorded surface electromyography to determine the time of actual movement, and electroencephalography to record brain potentials associated with movement. Results showed a significantly reduced interval between the reported M and W in patients with respect to the healthy volunteers (p < 0.05). Specifically, patients did not report a significant difference in the timing of W at 19 ms prior to movement onset and M at 7.4 ms prior to movement onset (p > 0.05), while the control group experienced a time W at 100 ms prior to movement onset and this differed significantly from their time M at 19 ms prior to movement onset (p < 0.01). These results suggest that patients with schizophrenia do have an altered timing of awareness of action – or an impaired judgment of the sequence of events – and that this might be etiologic in the development of the abnormal sense of agency.
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spelling pubmed-76624532020-11-13 Timing of the Sense of Volition in Patients With Schizophrenia Pirio Richardson, Sarah Triggiani, Antonio I. Matsuhashi, Masao Voon, Valerie Peckham, Elizabeth Nahab, Fatta Mari, Zoltan Hallett, Mark Front Neurosci Neuroscience Schizophrenic patients often do not have the sense that they direct their own movements or author their own thoughts (passivity phenomena). As willing must precede movement to be causal and thus generate the sense of agency, it is possible that the timing between the senses of willing and movement is shortened in schizophrenia. We tested the subjective perception of this time interval in patients with schizophrenia using a method based on Libet’s paradigm, in which subjects specify a time W – the time of willing a movement – and a time M – the time that movement occurred. Patients with schizophrenia and healthy volunteers made voluntary movements at times of their own choice while looking at a fast-rotating clock on a computer screen and reported when their movements were willed and made. We recorded surface electromyography to determine the time of actual movement, and electroencephalography to record brain potentials associated with movement. Results showed a significantly reduced interval between the reported M and W in patients with respect to the healthy volunteers (p < 0.05). Specifically, patients did not report a significant difference in the timing of W at 19 ms prior to movement onset and M at 7.4 ms prior to movement onset (p > 0.05), while the control group experienced a time W at 100 ms prior to movement onset and this differed significantly from their time M at 19 ms prior to movement onset (p < 0.01). These results suggest that patients with schizophrenia do have an altered timing of awareness of action – or an impaired judgment of the sequence of events – and that this might be etiologic in the development of the abnormal sense of agency. Frontiers Media S.A. 2020-10-30 /pmc/articles/PMC7662453/ /pubmed/33192259 http://dx.doi.org/10.3389/fnins.2020.574472 Text en Copyright © 2020 Pirio Richardson, Triggiani, Matsuhashi, Voon, Peckham, Nahab, Mari and Hallett. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Pirio Richardson, Sarah
Triggiani, Antonio I.
Matsuhashi, Masao
Voon, Valerie
Peckham, Elizabeth
Nahab, Fatta
Mari, Zoltan
Hallett, Mark
Timing of the Sense of Volition in Patients With Schizophrenia
title Timing of the Sense of Volition in Patients With Schizophrenia
title_full Timing of the Sense of Volition in Patients With Schizophrenia
title_fullStr Timing of the Sense of Volition in Patients With Schizophrenia
title_full_unstemmed Timing of the Sense of Volition in Patients With Schizophrenia
title_short Timing of the Sense of Volition in Patients With Schizophrenia
title_sort timing of the sense of volition in patients with schizophrenia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662453/
https://www.ncbi.nlm.nih.gov/pubmed/33192259
http://dx.doi.org/10.3389/fnins.2020.574472
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