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Synthesis and Biological Application of Polylactic Acid
Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662581/ https://www.ncbi.nlm.nih.gov/pubmed/33138232 http://dx.doi.org/10.3390/molecules25215023 |
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author | Li, Ge Zhao, Menghui Xu, Fei Yang, Bo Li, Xiangyu Meng, Xiangxue Teng, Lesheng Sun, Fengying Li, Youxin |
author_facet | Li, Ge Zhao, Menghui Xu, Fei Yang, Bo Li, Xiangyu Meng, Xiangxue Teng, Lesheng Sun, Fengying Li, Youxin |
author_sort | Li, Ge |
collection | PubMed |
description | Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications. |
format | Online Article Text |
id | pubmed-7662581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76625812020-11-14 Synthesis and Biological Application of Polylactic Acid Li, Ge Zhao, Menghui Xu, Fei Yang, Bo Li, Xiangyu Meng, Xiangxue Teng, Lesheng Sun, Fengying Li, Youxin Molecules Review Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications. MDPI 2020-10-29 /pmc/articles/PMC7662581/ /pubmed/33138232 http://dx.doi.org/10.3390/molecules25215023 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Ge Zhao, Menghui Xu, Fei Yang, Bo Li, Xiangyu Meng, Xiangxue Teng, Lesheng Sun, Fengying Li, Youxin Synthesis and Biological Application of Polylactic Acid |
title | Synthesis and Biological Application of Polylactic Acid |
title_full | Synthesis and Biological Application of Polylactic Acid |
title_fullStr | Synthesis and Biological Application of Polylactic Acid |
title_full_unstemmed | Synthesis and Biological Application of Polylactic Acid |
title_short | Synthesis and Biological Application of Polylactic Acid |
title_sort | synthesis and biological application of polylactic acid |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662581/ https://www.ncbi.nlm.nih.gov/pubmed/33138232 http://dx.doi.org/10.3390/molecules25215023 |
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