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Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?

Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanis...

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Autores principales: Rowles, Joanne Elizabeth, Keane, Kevin Noel, Gomes Heck, Thiago, Cruzat, Vinicius, Verdile, Giuseppe, Newsholme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662599/
https://www.ncbi.nlm.nih.gov/pubmed/33147803
http://dx.doi.org/10.3390/ijms21218204
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author Rowles, Joanne Elizabeth
Keane, Kevin Noel
Gomes Heck, Thiago
Cruzat, Vinicius
Verdile, Giuseppe
Newsholme, Philip
author_facet Rowles, Joanne Elizabeth
Keane, Kevin Noel
Gomes Heck, Thiago
Cruzat, Vinicius
Verdile, Giuseppe
Newsholme, Philip
author_sort Rowles, Joanne Elizabeth
collection PubMed
description Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanisms, including the deposition of amyloidogenic peptides in pancreatic islets (i.e., islet amyloid polypeptide; IAPP) and brain (β-Amyloid; Aβ). Both IAPP and Aβ can undergo misfolding and aggregation and accumulate in the extracellular space of their respective tissues of origin. As a main response to protein misfolding, there is evidence of the role of heat shock proteins (HSPs) in moderating T2D and AD. HSPs play a pivotal role in cell homeostasis by providing cytoprotection during acute and chronic metabolic stresses. In T2D and AD, intracellular HSP (iHSP) levels are reduced, potentially due to the ability of the cell to export HSPs to the extracellular space (eHSP). The increase in eHSPs can contribute to oxidative damage and is associated with various pro-inflammatory pathways in T2D and AD. Here, we review the role of HSP in moderating T2D and AD, as well as propose that these chaperone proteins are an important link in the relationship between T2D and AD.
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spelling pubmed-76625992020-11-14 Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease? Rowles, Joanne Elizabeth Keane, Kevin Noel Gomes Heck, Thiago Cruzat, Vinicius Verdile, Giuseppe Newsholme, Philip Int J Mol Sci Review Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanisms, including the deposition of amyloidogenic peptides in pancreatic islets (i.e., islet amyloid polypeptide; IAPP) and brain (β-Amyloid; Aβ). Both IAPP and Aβ can undergo misfolding and aggregation and accumulate in the extracellular space of their respective tissues of origin. As a main response to protein misfolding, there is evidence of the role of heat shock proteins (HSPs) in moderating T2D and AD. HSPs play a pivotal role in cell homeostasis by providing cytoprotection during acute and chronic metabolic stresses. In T2D and AD, intracellular HSP (iHSP) levels are reduced, potentially due to the ability of the cell to export HSPs to the extracellular space (eHSP). The increase in eHSPs can contribute to oxidative damage and is associated with various pro-inflammatory pathways in T2D and AD. Here, we review the role of HSP in moderating T2D and AD, as well as propose that these chaperone proteins are an important link in the relationship between T2D and AD. MDPI 2020-11-02 /pmc/articles/PMC7662599/ /pubmed/33147803 http://dx.doi.org/10.3390/ijms21218204 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rowles, Joanne Elizabeth
Keane, Kevin Noel
Gomes Heck, Thiago
Cruzat, Vinicius
Verdile, Giuseppe
Newsholme, Philip
Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?
title Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?
title_full Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?
title_fullStr Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?
title_full_unstemmed Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?
title_short Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?
title_sort are heat shock proteins an important link between type 2 diabetes and alzheimer disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662599/
https://www.ncbi.nlm.nih.gov/pubmed/33147803
http://dx.doi.org/10.3390/ijms21218204
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