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Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?
Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanis...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662599/ https://www.ncbi.nlm.nih.gov/pubmed/33147803 http://dx.doi.org/10.3390/ijms21218204 |
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author | Rowles, Joanne Elizabeth Keane, Kevin Noel Gomes Heck, Thiago Cruzat, Vinicius Verdile, Giuseppe Newsholme, Philip |
author_facet | Rowles, Joanne Elizabeth Keane, Kevin Noel Gomes Heck, Thiago Cruzat, Vinicius Verdile, Giuseppe Newsholme, Philip |
author_sort | Rowles, Joanne Elizabeth |
collection | PubMed |
description | Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanisms, including the deposition of amyloidogenic peptides in pancreatic islets (i.e., islet amyloid polypeptide; IAPP) and brain (β-Amyloid; Aβ). Both IAPP and Aβ can undergo misfolding and aggregation and accumulate in the extracellular space of their respective tissues of origin. As a main response to protein misfolding, there is evidence of the role of heat shock proteins (HSPs) in moderating T2D and AD. HSPs play a pivotal role in cell homeostasis by providing cytoprotection during acute and chronic metabolic stresses. In T2D and AD, intracellular HSP (iHSP) levels are reduced, potentially due to the ability of the cell to export HSPs to the extracellular space (eHSP). The increase in eHSPs can contribute to oxidative damage and is associated with various pro-inflammatory pathways in T2D and AD. Here, we review the role of HSP in moderating T2D and AD, as well as propose that these chaperone proteins are an important link in the relationship between T2D and AD. |
format | Online Article Text |
id | pubmed-7662599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76625992020-11-14 Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease? Rowles, Joanne Elizabeth Keane, Kevin Noel Gomes Heck, Thiago Cruzat, Vinicius Verdile, Giuseppe Newsholme, Philip Int J Mol Sci Review Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanisms, including the deposition of amyloidogenic peptides in pancreatic islets (i.e., islet amyloid polypeptide; IAPP) and brain (β-Amyloid; Aβ). Both IAPP and Aβ can undergo misfolding and aggregation and accumulate in the extracellular space of their respective tissues of origin. As a main response to protein misfolding, there is evidence of the role of heat shock proteins (HSPs) in moderating T2D and AD. HSPs play a pivotal role in cell homeostasis by providing cytoprotection during acute and chronic metabolic stresses. In T2D and AD, intracellular HSP (iHSP) levels are reduced, potentially due to the ability of the cell to export HSPs to the extracellular space (eHSP). The increase in eHSPs can contribute to oxidative damage and is associated with various pro-inflammatory pathways in T2D and AD. Here, we review the role of HSP in moderating T2D and AD, as well as propose that these chaperone proteins are an important link in the relationship between T2D and AD. MDPI 2020-11-02 /pmc/articles/PMC7662599/ /pubmed/33147803 http://dx.doi.org/10.3390/ijms21218204 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rowles, Joanne Elizabeth Keane, Kevin Noel Gomes Heck, Thiago Cruzat, Vinicius Verdile, Giuseppe Newsholme, Philip Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease? |
title | Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease? |
title_full | Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease? |
title_fullStr | Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease? |
title_full_unstemmed | Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease? |
title_short | Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease? |
title_sort | are heat shock proteins an important link between type 2 diabetes and alzheimer disease? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662599/ https://www.ncbi.nlm.nih.gov/pubmed/33147803 http://dx.doi.org/10.3390/ijms21218204 |
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