Cargando…

Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19

Progressive respiratory failure is seen as a major cause of death in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection. Relatively little is known about the associated morphologic and molecular changes in the circulation of these patients. In particular, platelet and ery...

Descripción completa

Detalles Bibliográficos
Autores principales:	Venter, Chantelle, Bezuidenhout, Johannes Andries, Laubscher, Gert Jacobus, Lourens, Petrus Johannes, Steenkamp, Janami, Kell, Douglas B., Pretorius, Etheresia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662625/ https://www.ncbi.nlm.nih.gov/pubmed/33153161 http://dx.doi.org/10.3390/ijms21218234

Ejemplares similares

Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report
por: Pretorius, Etheresia, et al.
Publicado: (2020)

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin
por: Pretorius, Etheresia, et al.
Publicado: (2021)

SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19
por: Grobbelaar, Lize M., et al.
Publicado: (2021)

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes
por: Grobler, Corlia, et al.
Publicado: (2020)

TEG(®), Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy
por: Laubscher, Gert Jacobus, et al.
Publicado: (2021)

Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system
por: Kruger, Arneaux, et al.
Publicado: (2022)

Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency
por: Bezuidenhout, Johannes A., et al.
Publicado: (2020)

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
por: Kell, Douglas B., et al.
Publicado: (2022)

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease
por: Bester, Janette, et al.
Publicado: (2013)

Platelet activity and hypercoagulation in type 2 diabetes
por: Pretorius, Lesha, et al.
Publicado: (2018)

Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)
por: Pretorius, Etheresia, et al.
Publicado: (2022)

Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model
por: Turner, Simone, et al.
Publicado: (2023)

Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability
por: Pretorius, Etheresia, et al.
Publicado: (2016)

Colorectal cancer is associated with increased circulating lipopolysaccharide, inflammation and hypercoagulability
por: de Waal, Greta M., et al.
Publicado: (2020)

Long COVID: pathophysiological factors and abnormalities of coagulation
por: Turner, Simone, et al.
Publicado: (2023)

Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents
por: Pretorius, Etheresia, et al.
Publicado: (2014)

Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics
por: Nunes, J. Massimo, et al.
Publicado: (2020)

Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
por: Randeria, Shehan N., et al.
Publicado: (2019)

Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity
por: Bester, Janette, et al.
Publicado: (2016)

Atypical erythrocytes and platelets in a patient with a pro-thrombin mutation
por: Pretorius, Etheresia, et al.
Publicado: (2014)

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics
por: Pretorius, Etheresia, et al.
Publicado: (2015)

Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer’s Type Dementia
por: Pretorius, Lesha, et al.
Publicado: (2018)

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases
por: Kell, Douglas B., et al.
Publicado: (2018)

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?
por: Kell, Douglas B., et al.
Publicado: (2018)

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications
por: Kell, Douglas B., et al.
Publicado: (2022)

Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function
por: Visser, Maria J. E., et al.
Publicado: (2021)

Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology
por: Kell, Douglas, et al.
Publicado: (2015)

Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis
por: Brun, Jean-Frédéric, et al.
Publicado: (2021)

Editorial: The immunological role of platelet activation in the pathophysiology of COVID-19
por: Rossouw, Theresa Marie, et al.
Publicado: (2023)

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease
por: Pretorius, Etheresia, et al.
Publicado: (2016)

Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities
por: Pretorius, Etheresia, et al.
Publicado: (2017)

Is Porphyromonas gingivalis involved in Parkinson’s disease?
por: Olsen, Ingar, et al.
Publicado: (2020)

The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management
por: Abou-Ismail, Mouhamed Yazan, et al.
Publicado: (2020)

The Bone Cement Hypercoagulation Syndrome: Pathophysiology, Mortality, and Prevention
por: Dahl, Ola E., et al.
Publicado: (2023)

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria
por: Kell, Douglas B., et al.
Publicado: (2020)

The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation
por: Page, Martin J., et al.
Publicado: (2022)

Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses
por: Nunes, Jean M., et al.
Publicado: (2023)

An estrogen analogue and promising anticancer agent refrains from inducing morphological damage and reactive oxygen species generation in erythrocytes, fibrin and platelets: a pilot study
por: Repsold, Lisa, et al.
Publicado: (2014)

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)
por: Bester, Janette, et al.
Publicado: (2015)

The dormant blood microbiome in chronic, inflammatory diseases
por: Potgieter, Marnie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_j938o6ehta1urdh4ihp2ig95a3