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Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study

The aim of this study was to investigate whether Timed Up-and-Go (TUG) dual-task (TUGdt) tests predict dementia incidence among patients with subjective or mild cognitive impairment (SCI; MCI). Other study objectives were to determine whether TUGdt improves dementia prediction compared to a) demogra...

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Autores principales: B Åhman, Hanna, Berglund, Lars, Cedervall, Ylva, Kilander, Lena, Giedraitis, Vilmantas, McKee, Kevin J., Ingelsson, Martin, Rosendahl, Erik, Åberg, Anna Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662628/
https://www.ncbi.nlm.nih.gov/pubmed/33153203
http://dx.doi.org/10.3390/ijerph17218129
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author B Åhman, Hanna
Berglund, Lars
Cedervall, Ylva
Kilander, Lena
Giedraitis, Vilmantas
McKee, Kevin J.
Ingelsson, Martin
Rosendahl, Erik
Åberg, Anna Cristina
author_facet B Åhman, Hanna
Berglund, Lars
Cedervall, Ylva
Kilander, Lena
Giedraitis, Vilmantas
McKee, Kevin J.
Ingelsson, Martin
Rosendahl, Erik
Åberg, Anna Cristina
author_sort B Åhman, Hanna
collection PubMed
description The aim of this study was to investigate whether Timed Up-and-Go (TUG) dual-task (TUGdt) tests predict dementia incidence among patients with subjective or mild cognitive impairment (SCI; MCI). Other study objectives were to determine whether TUGdt improves dementia prediction compared to a) demographic characteristics and standard cognitive tests alone; and b) TUG and Verbal Fluency performed separately. Patients (n = 172, age range 39–91 years, 78 women) with SCI or MCI performed TUGdt tests, including 1) naming animals and 2) reciting months backwards, and clinical cognitive tests at baseline. Diagnoses were identified at follow-up after 2.5 years. Logistic regression was used to predict dementia incidence, receiver operating characteristic (ROC) curves and c-statistics for predictive capacity. Analyses were stratified by age and gender. At follow-up, 51 patients had developed dementia. The TUGdt result “animals/10 s” was associated with dementia incidence (standardized odds ratio (OR) = 4.06, 95% confidence interval (CI) 2.28–7.23, p < 0.001), more so among patients under the median age of 72 years (standardized OR = 19.4, 95% CI 3.53–106.17, p < 0.001). TUGdt “animals/10 s” improved dementia prediction compared to demographic characteristics and standard tests alone (c-statistics 0.88 to 0.94) and single-task tests (c-statistics 0.86 to 0.89), but only in the younger patient group. TUGdt has the potential to become a useful tool for dementia prediction.
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spelling pubmed-76626282020-11-14 Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study B Åhman, Hanna Berglund, Lars Cedervall, Ylva Kilander, Lena Giedraitis, Vilmantas McKee, Kevin J. Ingelsson, Martin Rosendahl, Erik Åberg, Anna Cristina Int J Environ Res Public Health Article The aim of this study was to investigate whether Timed Up-and-Go (TUG) dual-task (TUGdt) tests predict dementia incidence among patients with subjective or mild cognitive impairment (SCI; MCI). Other study objectives were to determine whether TUGdt improves dementia prediction compared to a) demographic characteristics and standard cognitive tests alone; and b) TUG and Verbal Fluency performed separately. Patients (n = 172, age range 39–91 years, 78 women) with SCI or MCI performed TUGdt tests, including 1) naming animals and 2) reciting months backwards, and clinical cognitive tests at baseline. Diagnoses were identified at follow-up after 2.5 years. Logistic regression was used to predict dementia incidence, receiver operating characteristic (ROC) curves and c-statistics for predictive capacity. Analyses were stratified by age and gender. At follow-up, 51 patients had developed dementia. The TUGdt result “animals/10 s” was associated with dementia incidence (standardized odds ratio (OR) = 4.06, 95% confidence interval (CI) 2.28–7.23, p < 0.001), more so among patients under the median age of 72 years (standardized OR = 19.4, 95% CI 3.53–106.17, p < 0.001). TUGdt “animals/10 s” improved dementia prediction compared to demographic characteristics and standard tests alone (c-statistics 0.88 to 0.94) and single-task tests (c-statistics 0.86 to 0.89), but only in the younger patient group. TUGdt has the potential to become a useful tool for dementia prediction. MDPI 2020-11-03 2020-11 /pmc/articles/PMC7662628/ /pubmed/33153203 http://dx.doi.org/10.3390/ijerph17218129 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
B Åhman, Hanna
Berglund, Lars
Cedervall, Ylva
Kilander, Lena
Giedraitis, Vilmantas
McKee, Kevin J.
Ingelsson, Martin
Rosendahl, Erik
Åberg, Anna Cristina
Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study
title Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study
title_full Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study
title_fullStr Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study
title_full_unstemmed Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study
title_short Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study
title_sort dual-task tests predict conversion to dementia—a prospective memory-clinic-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662628/
https://www.ncbi.nlm.nih.gov/pubmed/33153203
http://dx.doi.org/10.3390/ijerph17218129
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