Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles

The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes, the regioselective alkylation and alkenylatio...

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Detalles Bibliográficos
Autores principales: Chen, Su, Ranjan, Prabhat, Voskressensky, Leonid G., Van der Eycken, Erik V., Sharma, Upendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662665/
https://www.ncbi.nlm.nih.gov/pubmed/33121108
http://dx.doi.org/10.3390/molecules25214970
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author Chen, Su
Ranjan, Prabhat
Voskressensky, Leonid G.
Van der Eycken, Erik V.
Sharma, Upendra K.
author_facet Chen, Su
Ranjan, Prabhat
Voskressensky, Leonid G.
Van der Eycken, Erik V.
Sharma, Upendra K.
author_sort Chen, Su
collection PubMed
description The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes, the regioselective alkylation and alkenylation of azoles are still arduous transformations in many cases. This review covers recent advances in the direct C–H alkenylation, alkylation and alkynylation of azoles utilizing transition metal-catalysis. Moreover, the limitations of different strategies, chemoselectivity and regioselectivity issues will be discussed in this review.
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spelling pubmed-76626652020-11-14 Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles Chen, Su Ranjan, Prabhat Voskressensky, Leonid G. Van der Eycken, Erik V. Sharma, Upendra K. Molecules Review The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes, the regioselective alkylation and alkenylation of azoles are still arduous transformations in many cases. This review covers recent advances in the direct C–H alkenylation, alkylation and alkynylation of azoles utilizing transition metal-catalysis. Moreover, the limitations of different strategies, chemoselectivity and regioselectivity issues will be discussed in this review. MDPI 2020-10-27 /pmc/articles/PMC7662665/ /pubmed/33121108 http://dx.doi.org/10.3390/molecules25214970 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Su
Ranjan, Prabhat
Voskressensky, Leonid G.
Van der Eycken, Erik V.
Sharma, Upendra K.
Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles
title Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles
title_full Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles
title_fullStr Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles
title_full_unstemmed Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles
title_short Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles
title_sort recent developments in transition-metal catalyzed direct c–h alkenylation, alkylation, and alkynylation of azoles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662665/
https://www.ncbi.nlm.nih.gov/pubmed/33121108
http://dx.doi.org/10.3390/molecules25214970
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