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Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study
Bioelectrical impedance analysis (BIA)-derived phase angle (PhA) is a valuable parameter to assess physical health. However, the genetic and environmental aspects of PhA are not yet well understood. The present study aimed to estimate the heritability of PhA and investigate the relationships between...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662672/ https://www.ncbi.nlm.nih.gov/pubmed/33114521 http://dx.doi.org/10.3390/ijerph17217810 |
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author | Matsumoto, Daisuke Inui, Fujio Honda, Chika Tomizawa, Rie Watanabe, Mikio Silventoinen, Karri Sakai, Norio |
author_facet | Matsumoto, Daisuke Inui, Fujio Honda, Chika Tomizawa, Rie Watanabe, Mikio Silventoinen, Karri Sakai, Norio |
author_sort | Matsumoto, Daisuke |
collection | PubMed |
description | Bioelectrical impedance analysis (BIA)-derived phase angle (PhA) is a valuable parameter to assess physical health. However, the genetic and environmental aspects of PhA are not yet well understood. The present study aimed to estimate the heritability of PhA and investigate the relationships between PhA and anthropometric measurements. PhA and skeletal muscle mass index (SMI) were examined using multi-frequency BIA in 168 Japanese twin volunteers (54 males and 114 females; mean age = 61.0 ± 16.5 years). We estimated the narrow-sense heritability of these parameters and the genetic and environmental relationships between them using a genetic twin modeling. For the PhA, 51% (95% confidence interval: 0.33, 0.64) of the variance was explained by additive genetic effects, and 49% (95% confidence interval: 0.36, 0.67) was explained by unique environmental effects. The heritability of PhA was lower than the height, body weight, and body mass index. PhA shared almost no genetic variation with anthropometric measurements and SMI but shared an environmental variation (14%) with SMI. These findings suggest that the genes affecting PhA are different than those affecting anthropometric measurements and SMI. The correlation between PhA and SMI is caused by common environmental factors. |
format | Online Article Text |
id | pubmed-7662672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76626722020-11-14 Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study Matsumoto, Daisuke Inui, Fujio Honda, Chika Tomizawa, Rie Watanabe, Mikio Silventoinen, Karri Sakai, Norio Int J Environ Res Public Health Article Bioelectrical impedance analysis (BIA)-derived phase angle (PhA) is a valuable parameter to assess physical health. However, the genetic and environmental aspects of PhA are not yet well understood. The present study aimed to estimate the heritability of PhA and investigate the relationships between PhA and anthropometric measurements. PhA and skeletal muscle mass index (SMI) were examined using multi-frequency BIA in 168 Japanese twin volunteers (54 males and 114 females; mean age = 61.0 ± 16.5 years). We estimated the narrow-sense heritability of these parameters and the genetic and environmental relationships between them using a genetic twin modeling. For the PhA, 51% (95% confidence interval: 0.33, 0.64) of the variance was explained by additive genetic effects, and 49% (95% confidence interval: 0.36, 0.67) was explained by unique environmental effects. The heritability of PhA was lower than the height, body weight, and body mass index. PhA shared almost no genetic variation with anthropometric measurements and SMI but shared an environmental variation (14%) with SMI. These findings suggest that the genes affecting PhA are different than those affecting anthropometric measurements and SMI. The correlation between PhA and SMI is caused by common environmental factors. MDPI 2020-10-26 2020-11 /pmc/articles/PMC7662672/ /pubmed/33114521 http://dx.doi.org/10.3390/ijerph17217810 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Matsumoto, Daisuke Inui, Fujio Honda, Chika Tomizawa, Rie Watanabe, Mikio Silventoinen, Karri Sakai, Norio Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study |
title | Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study |
title_full | Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study |
title_fullStr | Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study |
title_full_unstemmed | Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study |
title_short | Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study |
title_sort | heritability and environmental correlation of phase angle with anthropometric measurements: a twin study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662672/ https://www.ncbi.nlm.nih.gov/pubmed/33114521 http://dx.doi.org/10.3390/ijerph17217810 |
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