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Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic chronic inflammatory autoimmune joint disease, characterized by progressive articular damage and joint dysfunction. One of the symptoms of this disease is persistent inflammatory infiltration of the synovial membrane, the principle site of inflammation in RA....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662687/ https://www.ncbi.nlm.nih.gov/pubmed/33158216 http://dx.doi.org/10.3390/ijms21218265 |
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author | Szumilas, Kamila Szumilas, Paweł Słuczanowska-Głąbowska, Sylwia Zgutka, Katarzyna Pawlik, Andrzej |
author_facet | Szumilas, Kamila Szumilas, Paweł Słuczanowska-Głąbowska, Sylwia Zgutka, Katarzyna Pawlik, Andrzej |
author_sort | Szumilas, Kamila |
collection | PubMed |
description | Rheumatoid arthritis (RA) is a systemic chronic inflammatory autoimmune joint disease, characterized by progressive articular damage and joint dysfunction. One of the symptoms of this disease is persistent inflammatory infiltration of the synovial membrane, the principle site of inflammation in RA. In the affected conditions, the cells of the synovial membrane, fibroblast-like synoviocytes and macrophage-like synovial cells, produce enzymes degrading cartilage and underlining bone tissue, as well as cytokines increasing the infiltration of immune cells. In patients with RA, higher levels of adiponectin are measured in the serum and synovial fluid. Adiponectin, a secretory product that is mainly white adipose tissue, is a multifunctional protein with dual anti-inflammatory and pro-inflammatory properties. Several studies underline the fact that adiponectin can play an important pro-inflammatory role in the pathophysiology of RA via stimulating the secretion of inflammatory mediators. This narrative review is devoted to the presentation of recent knowledge on the role played by one of the adipokines produced by adipose tissue—adiponectin—in the pathogenesis of rheumatoid arthritis. |
format | Online Article Text |
id | pubmed-7662687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76626872020-11-14 Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis Szumilas, Kamila Szumilas, Paweł Słuczanowska-Głąbowska, Sylwia Zgutka, Katarzyna Pawlik, Andrzej Int J Mol Sci Review Rheumatoid arthritis (RA) is a systemic chronic inflammatory autoimmune joint disease, characterized by progressive articular damage and joint dysfunction. One of the symptoms of this disease is persistent inflammatory infiltration of the synovial membrane, the principle site of inflammation in RA. In the affected conditions, the cells of the synovial membrane, fibroblast-like synoviocytes and macrophage-like synovial cells, produce enzymes degrading cartilage and underlining bone tissue, as well as cytokines increasing the infiltration of immune cells. In patients with RA, higher levels of adiponectin are measured in the serum and synovial fluid. Adiponectin, a secretory product that is mainly white adipose tissue, is a multifunctional protein with dual anti-inflammatory and pro-inflammatory properties. Several studies underline the fact that adiponectin can play an important pro-inflammatory role in the pathophysiology of RA via stimulating the secretion of inflammatory mediators. This narrative review is devoted to the presentation of recent knowledge on the role played by one of the adipokines produced by adipose tissue—adiponectin—in the pathogenesis of rheumatoid arthritis. MDPI 2020-11-04 /pmc/articles/PMC7662687/ /pubmed/33158216 http://dx.doi.org/10.3390/ijms21218265 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szumilas, Kamila Szumilas, Paweł Słuczanowska-Głąbowska, Sylwia Zgutka, Katarzyna Pawlik, Andrzej Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis |
title | Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis |
title_full | Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis |
title_fullStr | Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis |
title_full_unstemmed | Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis |
title_short | Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis |
title_sort | role of adiponectin in the pathogenesis of rheumatoid arthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662687/ https://www.ncbi.nlm.nih.gov/pubmed/33158216 http://dx.doi.org/10.3390/ijms21218265 |
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