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Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing
The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662692/ https://www.ncbi.nlm.nih.gov/pubmed/33153027 http://dx.doi.org/10.3390/molecules25215096 |
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author | Kowalczuk, Dorota Miazga-Karska, Małgorzata Gładysz, Agata Warda, Paweł Barańska, Agnieszka Drop, Bartłomiej |
author_facet | Kowalczuk, Dorota Miazga-Karska, Małgorzata Gładysz, Agata Warda, Paweł Barańska, Agnieszka Drop, Bartłomiej |
author_sort | Kowalczuk, Dorota |
collection | PubMed |
description | The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dressing was obtained by modification of the raw dressing with an iodine or bromine solution and subsequently with a Cip-Bi hydrogel. The amount of Cip-Bi loaded into the dressing matrix was determined indirectly on the basis of the differences in Cip-Bi concentrations, before and after the modification process, and the determination was performed with the HPLC (high-performance liquid chromatography) method. The modified dressing was found to have a two-step release of Cip-Bi, a feature helpful in the treatment of locally infected wounds and prevention of secondary bacterial infection. The zone of inhibition test against the selected Gram-positive and Gram-negative bacteria confirmed the antibacterial activity of the Cip-Bi-modified dressing. Preliminary tests conducted so far have been indicative of the Cip-Bi dressing’s relatively high activity against the tested organisms. |
format | Online Article Text |
id | pubmed-7662692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76626922020-11-14 Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing Kowalczuk, Dorota Miazga-Karska, Małgorzata Gładysz, Agata Warda, Paweł Barańska, Agnieszka Drop, Bartłomiej Molecules Article The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dressing was obtained by modification of the raw dressing with an iodine or bromine solution and subsequently with a Cip-Bi hydrogel. The amount of Cip-Bi loaded into the dressing matrix was determined indirectly on the basis of the differences in Cip-Bi concentrations, before and after the modification process, and the determination was performed with the HPLC (high-performance liquid chromatography) method. The modified dressing was found to have a two-step release of Cip-Bi, a feature helpful in the treatment of locally infected wounds and prevention of secondary bacterial infection. The zone of inhibition test against the selected Gram-positive and Gram-negative bacteria confirmed the antibacterial activity of the Cip-Bi-modified dressing. Preliminary tests conducted so far have been indicative of the Cip-Bi dressing’s relatively high activity against the tested organisms. MDPI 2020-11-03 /pmc/articles/PMC7662692/ /pubmed/33153027 http://dx.doi.org/10.3390/molecules25215096 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kowalczuk, Dorota Miazga-Karska, Małgorzata Gładysz, Agata Warda, Paweł Barańska, Agnieszka Drop, Bartłomiej Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
title | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
title_full | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
title_fullStr | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
title_full_unstemmed | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
title_short | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
title_sort | characterization of ciprofloxacin-bismuth-loaded antibacterial wound dressing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662692/ https://www.ncbi.nlm.nih.gov/pubmed/33153027 http://dx.doi.org/10.3390/molecules25215096 |
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