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Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing

The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dr...

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Autores principales: Kowalczuk, Dorota, Miazga-Karska, Małgorzata, Gładysz, Agata, Warda, Paweł, Barańska, Agnieszka, Drop, Bartłomiej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662692/
https://www.ncbi.nlm.nih.gov/pubmed/33153027
http://dx.doi.org/10.3390/molecules25215096
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author Kowalczuk, Dorota
Miazga-Karska, Małgorzata
Gładysz, Agata
Warda, Paweł
Barańska, Agnieszka
Drop, Bartłomiej
author_facet Kowalczuk, Dorota
Miazga-Karska, Małgorzata
Gładysz, Agata
Warda, Paweł
Barańska, Agnieszka
Drop, Bartłomiej
author_sort Kowalczuk, Dorota
collection PubMed
description The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dressing was obtained by modification of the raw dressing with an iodine or bromine solution and subsequently with a Cip-Bi hydrogel. The amount of Cip-Bi loaded into the dressing matrix was determined indirectly on the basis of the differences in Cip-Bi concentrations, before and after the modification process, and the determination was performed with the HPLC (high-performance liquid chromatography) method. The modified dressing was found to have a two-step release of Cip-Bi, a feature helpful in the treatment of locally infected wounds and prevention of secondary bacterial infection. The zone of inhibition test against the selected Gram-positive and Gram-negative bacteria confirmed the antibacterial activity of the Cip-Bi-modified dressing. Preliminary tests conducted so far have been indicative of the Cip-Bi dressing’s relatively high activity against the tested organisms.
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spelling pubmed-76626922020-11-14 Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing Kowalczuk, Dorota Miazga-Karska, Małgorzata Gładysz, Agata Warda, Paweł Barańska, Agnieszka Drop, Bartłomiej Molecules Article The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dressing was obtained by modification of the raw dressing with an iodine or bromine solution and subsequently with a Cip-Bi hydrogel. The amount of Cip-Bi loaded into the dressing matrix was determined indirectly on the basis of the differences in Cip-Bi concentrations, before and after the modification process, and the determination was performed with the HPLC (high-performance liquid chromatography) method. The modified dressing was found to have a two-step release of Cip-Bi, a feature helpful in the treatment of locally infected wounds and prevention of secondary bacterial infection. The zone of inhibition test against the selected Gram-positive and Gram-negative bacteria confirmed the antibacterial activity of the Cip-Bi-modified dressing. Preliminary tests conducted so far have been indicative of the Cip-Bi dressing’s relatively high activity against the tested organisms. MDPI 2020-11-03 /pmc/articles/PMC7662692/ /pubmed/33153027 http://dx.doi.org/10.3390/molecules25215096 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kowalczuk, Dorota
Miazga-Karska, Małgorzata
Gładysz, Agata
Warda, Paweł
Barańska, Agnieszka
Drop, Bartłomiej
Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing
title Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing
title_full Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing
title_fullStr Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing
title_full_unstemmed Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing
title_short Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing
title_sort characterization of ciprofloxacin-bismuth-loaded antibacterial wound dressing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662692/
https://www.ncbi.nlm.nih.gov/pubmed/33153027
http://dx.doi.org/10.3390/molecules25215096
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