Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions

Non-competitive N-methyl-D-aspartate/glutamate receptor (NMDAR) antagonism has been considered to play important roles in the pathophysiology of schizophrenia. In spite of severe neuropsychiatric adverse effects, esketamine (racemic enantiomer of ketamine) has been approved for the treatment of conv...

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Detalles Bibliográficos
Autores principales: Okada, Motohiro, Kawano, Yasuhiro, Fukuyama, Kouji, Motomura, Eishi, Shiroyama, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662754/
https://www.ncbi.nlm.nih.gov/pubmed/33114753
http://dx.doi.org/10.3390/ijms21217951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662754/
https://www.ncbi.nlm.nih.gov/pubmed/33114753
http://dx.doi.org/10.3390/ijms21217951

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