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Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes

Natural calcium phosphates derived from fish wastes are a promising material for biomedical application. However, their sintered ceramics are not fully characterized in terms of mechanical and biological properties. In this study, natural calcium phosphate was synthesized through a thermal calcinati...

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Autores principales: Bas, Merve, Daglilar, Sibel, Kuskonmaz, Nilgun, Kalkandelen, Cevriye, Erdemir, Gokce, Kuruca, Serap E., Tulyaganov, Dilshat, Yoshioka, Tomohiko, Gunduz, Oguzhan, Ficai, Denisa, Ficai, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662779/
https://www.ncbi.nlm.nih.gov/pubmed/33138182
http://dx.doi.org/10.3390/ijms21218082
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author Bas, Merve
Daglilar, Sibel
Kuskonmaz, Nilgun
Kalkandelen, Cevriye
Erdemir, Gokce
Kuruca, Serap E.
Tulyaganov, Dilshat
Yoshioka, Tomohiko
Gunduz, Oguzhan
Ficai, Denisa
Ficai, Anton
author_facet Bas, Merve
Daglilar, Sibel
Kuskonmaz, Nilgun
Kalkandelen, Cevriye
Erdemir, Gokce
Kuruca, Serap E.
Tulyaganov, Dilshat
Yoshioka, Tomohiko
Gunduz, Oguzhan
Ficai, Denisa
Ficai, Anton
author_sort Bas, Merve
collection PubMed
description Natural calcium phosphates derived from fish wastes are a promising material for biomedical application. However, their sintered ceramics are not fully characterized in terms of mechanical and biological properties. In this study, natural calcium phosphate was synthesized through a thermal calcination process from salmon fish bone wastes. The salmon-derived calcium phosphates (sCaP) were sintered at different temperatures to obtain natural calcium phosphate bioceramics and then were investigated in terms of their microstructure, mechanical properties and biocompatibility. In particular, this work is concerned with the effects of grain size on the relative density and microhardness of the sCaP bioceramics. Ca/P ratio of the sintered sCaP ranged from 1.73 to 1.52 when the sintering temperature was raised from 1000 to 1300 °C. The crystal phase of all the sCaP bioceramics obtained was biphasic and composed of hydroxyapatite (HA) and tricalcium phosphate (TCP). The density and microhardness of the sCaP bioceramics increased in the temperature interval 1000–1100 °C, while at temperatures higher than 1100 °C, these properties were not significantly altered. The highest compressive strength of 116 MPa was recorded for the samples sintered at 1100 °C. In vitro biocompatibility was also examined in the behavior of osteosarcoma (Saos-2) cells, indicating that the sCaP bioceramics had no cytotoxicity effect. Salmon-derived biphasic calcium phosphates (BCP) have the potential to contribute to the development of bone substituted materials.
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spelling pubmed-76627792020-11-14 Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes Bas, Merve Daglilar, Sibel Kuskonmaz, Nilgun Kalkandelen, Cevriye Erdemir, Gokce Kuruca, Serap E. Tulyaganov, Dilshat Yoshioka, Tomohiko Gunduz, Oguzhan Ficai, Denisa Ficai, Anton Int J Mol Sci Article Natural calcium phosphates derived from fish wastes are a promising material for biomedical application. However, their sintered ceramics are not fully characterized in terms of mechanical and biological properties. In this study, natural calcium phosphate was synthesized through a thermal calcination process from salmon fish bone wastes. The salmon-derived calcium phosphates (sCaP) were sintered at different temperatures to obtain natural calcium phosphate bioceramics and then were investigated in terms of their microstructure, mechanical properties and biocompatibility. In particular, this work is concerned with the effects of grain size on the relative density and microhardness of the sCaP bioceramics. Ca/P ratio of the sintered sCaP ranged from 1.73 to 1.52 when the sintering temperature was raised from 1000 to 1300 °C. The crystal phase of all the sCaP bioceramics obtained was biphasic and composed of hydroxyapatite (HA) and tricalcium phosphate (TCP). The density and microhardness of the sCaP bioceramics increased in the temperature interval 1000–1100 °C, while at temperatures higher than 1100 °C, these properties were not significantly altered. The highest compressive strength of 116 MPa was recorded for the samples sintered at 1100 °C. In vitro biocompatibility was also examined in the behavior of osteosarcoma (Saos-2) cells, indicating that the sCaP bioceramics had no cytotoxicity effect. Salmon-derived biphasic calcium phosphates (BCP) have the potential to contribute to the development of bone substituted materials. MDPI 2020-10-29 /pmc/articles/PMC7662779/ /pubmed/33138182 http://dx.doi.org/10.3390/ijms21218082 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bas, Merve
Daglilar, Sibel
Kuskonmaz, Nilgun
Kalkandelen, Cevriye
Erdemir, Gokce
Kuruca, Serap E.
Tulyaganov, Dilshat
Yoshioka, Tomohiko
Gunduz, Oguzhan
Ficai, Denisa
Ficai, Anton
Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes
title Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes
title_full Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes
title_fullStr Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes
title_full_unstemmed Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes
title_short Mechanical and Biocompatibility Properties of Calcium Phosphate Bioceramics Derived from Salmon Fish Bone Wastes
title_sort mechanical and biocompatibility properties of calcium phosphate bioceramics derived from salmon fish bone wastes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662779/
https://www.ncbi.nlm.nih.gov/pubmed/33138182
http://dx.doi.org/10.3390/ijms21218082
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