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In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
Oxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear impr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662866/ https://www.ncbi.nlm.nih.gov/pubmed/33142791 http://dx.doi.org/10.3390/ijms21218156 |
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author | Giraud, Sebastien Thuillier, Raphaël Cau, Jérome Hauet, Thierry |
author_facet | Giraud, Sebastien Thuillier, Raphaël Cau, Jérome Hauet, Thierry |
author_sort | Giraud, Sebastien |
collection | PubMed |
description | Oxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear improvement of preservation quality, particularly for marginal donors, such as extended criteria donors (ECDs) and donation after circulatory death (DCDs). Nevertheless, complications still exist, fostering the need to improve kidney preservation. This review highlights the most promising avenues of in kidney perfusion improvement on two critical aspects: ex vivo and in vitro evaluation. |
format | Online Article Text |
id | pubmed-7662866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76628662020-11-14 In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion Giraud, Sebastien Thuillier, Raphaël Cau, Jérome Hauet, Thierry Int J Mol Sci Review Oxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear improvement of preservation quality, particularly for marginal donors, such as extended criteria donors (ECDs) and donation after circulatory death (DCDs). Nevertheless, complications still exist, fostering the need to improve kidney preservation. This review highlights the most promising avenues of in kidney perfusion improvement on two critical aspects: ex vivo and in vitro evaluation. MDPI 2020-10-31 /pmc/articles/PMC7662866/ /pubmed/33142791 http://dx.doi.org/10.3390/ijms21218156 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Giraud, Sebastien Thuillier, Raphaël Cau, Jérome Hauet, Thierry In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
title | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
title_full | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
title_fullStr | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
title_full_unstemmed | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
title_short | In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion |
title_sort | in vitro/ex vivo models for the study of ischemia reperfusion injury during kidney perfusion |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662866/ https://www.ncbi.nlm.nih.gov/pubmed/33142791 http://dx.doi.org/10.3390/ijms21218156 |
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