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In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion

Oxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear impr...

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Autores principales: Giraud, Sebastien, Thuillier, Raphaël, Cau, Jérome, Hauet, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662866/
https://www.ncbi.nlm.nih.gov/pubmed/33142791
http://dx.doi.org/10.3390/ijms21218156
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author Giraud, Sebastien
Thuillier, Raphaël
Cau, Jérome
Hauet, Thierry
author_facet Giraud, Sebastien
Thuillier, Raphaël
Cau, Jérome
Hauet, Thierry
author_sort Giraud, Sebastien
collection PubMed
description Oxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear improvement of preservation quality, particularly for marginal donors, such as extended criteria donors (ECDs) and donation after circulatory death (DCDs). Nevertheless, complications still exist, fostering the need to improve kidney preservation. This review highlights the most promising avenues of in kidney perfusion improvement on two critical aspects: ex vivo and in vitro evaluation.
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spelling pubmed-76628662020-11-14 In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion Giraud, Sebastien Thuillier, Raphaël Cau, Jérome Hauet, Thierry Int J Mol Sci Review Oxidative stress is a key element of ischemia–reperfusion injury, occurring during kidney preservation and transplantation. Current options for kidney graft preservation prior to transplantation are static cold storage (CS) and hypothermic machine perfusion (HMP), the latter demonstrating clear improvement of preservation quality, particularly for marginal donors, such as extended criteria donors (ECDs) and donation after circulatory death (DCDs). Nevertheless, complications still exist, fostering the need to improve kidney preservation. This review highlights the most promising avenues of in kidney perfusion improvement on two critical aspects: ex vivo and in vitro evaluation. MDPI 2020-10-31 /pmc/articles/PMC7662866/ /pubmed/33142791 http://dx.doi.org/10.3390/ijms21218156 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giraud, Sebastien
Thuillier, Raphaël
Cau, Jérome
Hauet, Thierry
In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
title In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
title_full In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
title_fullStr In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
title_full_unstemmed In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
title_short In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
title_sort in vitro/ex vivo models for the study of ischemia reperfusion injury during kidney perfusion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662866/
https://www.ncbi.nlm.nih.gov/pubmed/33142791
http://dx.doi.org/10.3390/ijms21218156
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