The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression

High-grade serous carcinoma (HGSC), the most lethal subtype of epithelial ovarian cancer (EOC), is characterized by widespread TP53 mutations (>90%), most of which are missense mutations (>70%). The objective of this study was to investigate differential transcriptional targets affected by a c...

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Detalles Bibliográficos
Autores principales: De Souza, Cristabelle, Madden, Jill A., Minn, Dennis, Kumar, Vigneshwari Easwar, Montoya, Dennis J., Nambiar, Roshni, Zhu, Zheng, Xiao, Wen-Wu, Tahmassebi, Neeki, Kathi, Harikumara, Nelson, Nina, Karnezis, Anthony N., Chien, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662892/
https://www.ncbi.nlm.nih.gov/pubmed/33126568
http://dx.doi.org/10.3390/ijms21218025

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