Protein Binding of Lapatinib and Its N- and O-Dealkylated Metabolites Interrogated by Fluorescence, Ultrafast Spectroscopy and Molecular Dynamics Simulations

Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological adverse effects and photosensitivity. Moreover, LAP binds to serum proteins and is readily biotransformed in humans, giving rise to several metab...

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Detalles Bibliográficos
Autores principales: Andreu, Inmaculada, Lence, Emilio, González-Bello, Concepción, Mayorga, Cristobalina, Cuquerella, M. Consuelo, Vayá, Ignacio, Miranda, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662899/
https://www.ncbi.nlm.nih.gov/pubmed/33192518
http://dx.doi.org/10.3389/fphar.2020.576495

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