Histone Deacetylase Inhibitors as Multitarget-Directed Epi-Drugs in Blocking PI3K Oncogenic Signaling: A Polypharmacology Approach

Genetic mutations and aberrant epigenetic alterations are the triggers for carcinogenesis. The emergence of the drugs targeting epigenetic aberrations has provided a better outlook for cancer treatment. Histone deacetylases (HDACs) are epigenetic modifiers playing critical roles in numerous key biol...

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Detalles Bibliográficos
Autores principales: Ranganna, Kasturi, Selvam, Chelliah, Shivachar, Amruthesh, Yousefipour, Zivar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662987/
https://www.ncbi.nlm.nih.gov/pubmed/33147762
http://dx.doi.org/10.3390/ijms21218198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662987/
https://www.ncbi.nlm.nih.gov/pubmed/33147762
http://dx.doi.org/10.3390/ijms21218198

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