Discovery of 5-Phenoxy-2-aminopyridine Derivatives as Potent and Selective Irreversible Inhibitors of Bruton’s Tyrosine Kinase

As a member of the tyrosine protein kinase Tec (TEC) family, Bruton’s tyrosine kinase (BTK) is considered a promising therapeutic target due to its crucial roles in the B cell receptor (BCR) signaling pathway. Although many types of BTK inhibitors have been reported, there is an unmet need to achiev...

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Detalles Bibliográficos
Autores principales: Lee, Eun, Cho, Hyewon, Lee, Da Kyung, Ha, JuHyun, Choi, Byeong Jo, Jeong, Ji Hye, Ryu, Jae-Ha, Kang, Jong Soon, Jeon, Raok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663149/
https://www.ncbi.nlm.nih.gov/pubmed/33126415
http://dx.doi.org/10.3390/ijms21218006

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