K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity

Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest ta...

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Autores principales: Kowalska, Magdalena, Nowaczyk, Jacek, Nowaczyk, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663169/
https://www.ncbi.nlm.nih.gov/pubmed/33143033
http://dx.doi.org/10.3390/ijms21218099
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author Kowalska, Magdalena
Nowaczyk, Jacek
Nowaczyk, Alicja
author_facet Kowalska, Magdalena
Nowaczyk, Jacek
Nowaczyk, Alicja
author_sort Kowalska, Magdalena
collection PubMed
description Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest target. As mentioned in the literature, ion channels are an indispensable part of the heart’s work. In this paper the most important information concerning the guidelines for cardiotoxicity testing and the way the tests are conducted has been collected. Attention has been focused on the role of selected ion channels in this process.
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spelling pubmed-76631692020-11-14 K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity Kowalska, Magdalena Nowaczyk, Jacek Nowaczyk, Alicja Int J Mol Sci Review Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest target. As mentioned in the literature, ion channels are an indispensable part of the heart’s work. In this paper the most important information concerning the guidelines for cardiotoxicity testing and the way the tests are conducted has been collected. Attention has been focused on the role of selected ion channels in this process. MDPI 2020-10-30 /pmc/articles/PMC7663169/ /pubmed/33143033 http://dx.doi.org/10.3390/ijms21218099 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kowalska, Magdalena
Nowaczyk, Jacek
Nowaczyk, Alicja
K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
title K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
title_full K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
title_fullStr K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
title_full_unstemmed K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
title_short K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
title_sort k(v)11.1, na(v)1.5, and ca(v)1.2 transporter proteins as antitarget for drug cardiotoxicity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663169/
https://www.ncbi.nlm.nih.gov/pubmed/33143033
http://dx.doi.org/10.3390/ijms21218099
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AT nowaczykalicja kv111nav15andcav12transporterproteinsasantitargetfordrugcardiotoxicity

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