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Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease
Alzheimer’s disease (AD) is characterized by memory dysfunction, Aβ plaques together with phosphorylated tau-associated neurofibrillary tangles. Unfortunately, the present existing drugs for AD only offer mild symptomatic cure and have more side effects. As such, developments of effective, nontoxic...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663173/ https://www.ncbi.nlm.nih.gov/pubmed/33192524 http://dx.doi.org/10.3389/fphar.2020.584770 |
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author | Iyaswamy, A. Krishnamoorthi, S. K. Liu, Y. W. Song, J. X. Kammala, A. K. Sreenivasmurthy, S. G. Malampati, S. Tong, B. C. K. Selvarasu, K. Cheung, K. H. Lu, J. H. Tan, J. Q. Huang, C. Y. Durairajan, S. S. K. Li, M. |
author_facet | Iyaswamy, A. Krishnamoorthi, S. K. Liu, Y. W. Song, J. X. Kammala, A. K. Sreenivasmurthy, S. G. Malampati, S. Tong, B. C. K. Selvarasu, K. Cheung, K. H. Lu, J. H. Tan, J. Q. Huang, C. Y. Durairajan, S. S. K. Li, M. |
author_sort | Iyaswamy, A. |
collection | PubMed |
description | Alzheimer’s disease (AD) is characterized by memory dysfunction, Aβ plaques together with phosphorylated tau-associated neurofibrillary tangles. Unfortunately, the present existing drugs for AD only offer mild symptomatic cure and have more side effects. As such, developments of effective, nontoxic drugs are immediately required for AD therapy. Present study demonstrates a novel role of Chinese medicine prescription Yuan-Hu Zhi Tong (YZT) in treating AD, and it has substantiated the in vivo effectiveness of YZT in two different transgenic mice models of AD, namely P301S tau and 3XTg-AD mice. Oral treatment of YZT significantly ameliorates motor dysfunction as well as promotes the clearance of aggregated tau in P301S tau mice. YZT improves the cognitive function and reduces the insoluble tau aggregates in 3XTg-AD mice model. Furthermore, YZT decreases the insoluble AT8 positive neuron load in both P301S tau and 3XTg-AD mice. Using microarray and the “Connectivity Map” analysis, we determined the YZT-induced changes in expression of signaling molecules and revealed the potential mechanism of action of YZT. YZT might regulate ubiquitin proteasomal system for the degradation of tau aggregates. The research results show that YZT is a potential drug candidate for the therapy of tau pathogenesis and memory decline in AD. |
format | Online Article Text |
id | pubmed-7663173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76631732020-11-13 Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease Iyaswamy, A. Krishnamoorthi, S. K. Liu, Y. W. Song, J. X. Kammala, A. K. Sreenivasmurthy, S. G. Malampati, S. Tong, B. C. K. Selvarasu, K. Cheung, K. H. Lu, J. H. Tan, J. Q. Huang, C. Y. Durairajan, S. S. K. Li, M. Front Pharmacol Pharmacology Alzheimer’s disease (AD) is characterized by memory dysfunction, Aβ plaques together with phosphorylated tau-associated neurofibrillary tangles. Unfortunately, the present existing drugs for AD only offer mild symptomatic cure and have more side effects. As such, developments of effective, nontoxic drugs are immediately required for AD therapy. Present study demonstrates a novel role of Chinese medicine prescription Yuan-Hu Zhi Tong (YZT) in treating AD, and it has substantiated the in vivo effectiveness of YZT in two different transgenic mice models of AD, namely P301S tau and 3XTg-AD mice. Oral treatment of YZT significantly ameliorates motor dysfunction as well as promotes the clearance of aggregated tau in P301S tau mice. YZT improves the cognitive function and reduces the insoluble tau aggregates in 3XTg-AD mice model. Furthermore, YZT decreases the insoluble AT8 positive neuron load in both P301S tau and 3XTg-AD mice. Using microarray and the “Connectivity Map” analysis, we determined the YZT-induced changes in expression of signaling molecules and revealed the potential mechanism of action of YZT. YZT might regulate ubiquitin proteasomal system for the degradation of tau aggregates. The research results show that YZT is a potential drug candidate for the therapy of tau pathogenesis and memory decline in AD. Frontiers Media S.A. 2020-10-30 /pmc/articles/PMC7663173/ /pubmed/33192524 http://dx.doi.org/10.3389/fphar.2020.584770 Text en Copyright © 2020 Iyaswamy, Krishnamoorthi, Liu, Song, Kammala, Sreenivasmurthy, Malampati, Chun-Kit Tong, Selvarasu, CHEUNG, Lu, Tan, Huang, Durairajan and Min http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Iyaswamy, A. Krishnamoorthi, S. K. Liu, Y. W. Song, J. X. Kammala, A. K. Sreenivasmurthy, S. G. Malampati, S. Tong, B. C. K. Selvarasu, K. Cheung, K. H. Lu, J. H. Tan, J. Q. Huang, C. Y. Durairajan, S. S. K. Li, M. Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease |
title | Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease |
title_full | Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease |
title_fullStr | Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease |
title_full_unstemmed | Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease |
title_short | Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease |
title_sort | yuan-hu zhi tong prescription mitigates tau pathology and alleviates memory deficiency in the preclinical models of alzheimer’s disease |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663173/ https://www.ncbi.nlm.nih.gov/pubmed/33192524 http://dx.doi.org/10.3389/fphar.2020.584770 |
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