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Platelets, Thrombocytosis, and Ovarian Cancer Prognosis: Surveying the Landscape of the Literature
Platelets are critical components of a number of physiologic processes, including tissue remodeling after injury, wound healing, and maintenance of vascular integrity. Increasing evidence suggests that platelets may also play important roles in cancer. In ovarian cancer, thrombocytosis, both at the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663176/ https://www.ncbi.nlm.nih.gov/pubmed/33142915 http://dx.doi.org/10.3390/ijms21218169 |
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author | Hufnagel, Demetra H. Cozzi, Gabriella D. Crispens, Marta A. Beeghly-Fadiel, Alicia |
author_facet | Hufnagel, Demetra H. Cozzi, Gabriella D. Crispens, Marta A. Beeghly-Fadiel, Alicia |
author_sort | Hufnagel, Demetra H. |
collection | PubMed |
description | Platelets are critical components of a number of physiologic processes, including tissue remodeling after injury, wound healing, and maintenance of vascular integrity. Increasing evidence suggests that platelets may also play important roles in cancer. In ovarian cancer, thrombocytosis, both at the time of initial diagnosis and at recurrence, has been associated with poorer prognosis. This review describes current evidence for associations between thrombocytosis and ovarian cancer prognosis and discusses the clinical relevance of platelet count thresholds and timing of assessment. In addition, we discuss several mechanisms from in vitro, in vivo, and clinical studies that may underlie these associations and recommend potential approaches for novel therapeutic targets for this lethal disease. |
format | Online Article Text |
id | pubmed-7663176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76631762020-11-14 Platelets, Thrombocytosis, and Ovarian Cancer Prognosis: Surveying the Landscape of the Literature Hufnagel, Demetra H. Cozzi, Gabriella D. Crispens, Marta A. Beeghly-Fadiel, Alicia Int J Mol Sci Review Platelets are critical components of a number of physiologic processes, including tissue remodeling after injury, wound healing, and maintenance of vascular integrity. Increasing evidence suggests that platelets may also play important roles in cancer. In ovarian cancer, thrombocytosis, both at the time of initial diagnosis and at recurrence, has been associated with poorer prognosis. This review describes current evidence for associations between thrombocytosis and ovarian cancer prognosis and discusses the clinical relevance of platelet count thresholds and timing of assessment. In addition, we discuss several mechanisms from in vitro, in vivo, and clinical studies that may underlie these associations and recommend potential approaches for novel therapeutic targets for this lethal disease. MDPI 2020-10-31 /pmc/articles/PMC7663176/ /pubmed/33142915 http://dx.doi.org/10.3390/ijms21218169 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hufnagel, Demetra H. Cozzi, Gabriella D. Crispens, Marta A. Beeghly-Fadiel, Alicia Platelets, Thrombocytosis, and Ovarian Cancer Prognosis: Surveying the Landscape of the Literature |
title | Platelets, Thrombocytosis, and Ovarian Cancer Prognosis: Surveying the Landscape of the Literature |
title_full | Platelets, Thrombocytosis, and Ovarian Cancer Prognosis: Surveying the Landscape of the Literature |
title_fullStr | Platelets, Thrombocytosis, and Ovarian Cancer Prognosis: Surveying the Landscape of the Literature |
title_full_unstemmed | Platelets, Thrombocytosis, and Ovarian Cancer Prognosis: Surveying the Landscape of the Literature |
title_short | Platelets, Thrombocytosis, and Ovarian Cancer Prognosis: Surveying the Landscape of the Literature |
title_sort | platelets, thrombocytosis, and ovarian cancer prognosis: surveying the landscape of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663176/ https://www.ncbi.nlm.nih.gov/pubmed/33142915 http://dx.doi.org/10.3390/ijms21218169 |
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