QSAR Implementation for HIC Retention Time Prediction of mAbs Using Fab Structure: A Comparison between Structural Representations

Monoclonal antibodies (mAbs) constitute a rapidly growing biopharmaceutical sector. However, their growth is impeded by high failure rates originating from failed clinical trials and developability issues in process development. There is, therefore, a growing need for better in silico tools to aid i...

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Detalles Bibliográficos
Autores principales: Karlberg, Micael, de Souza, João Victor, Fan, Lanyu, Kizhedath, Arathi, Bronowska, Agnieszka K., Glassey, Jarka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663183/
https://www.ncbi.nlm.nih.gov/pubmed/33126648
http://dx.doi.org/10.3390/ijms21218037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663183/
https://www.ncbi.nlm.nih.gov/pubmed/33126648
http://dx.doi.org/10.3390/ijms21218037

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