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CCL18 in the Progression of Cancer
A neoplastic tumor consists of cancer cells that interact with each other and non-cancerous cells that support the development of the cancer. One such cell are tumor-associated macrophages (TAMs). These cells secrete many chemokines into the tumor microenvironment, including especially a large amoun...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663205/ https://www.ncbi.nlm.nih.gov/pubmed/33114763 http://dx.doi.org/10.3390/ijms21217955 |
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author | Korbecki, Jan Olbromski, Mateusz Dzięgiel, Piotr |
author_facet | Korbecki, Jan Olbromski, Mateusz Dzięgiel, Piotr |
author_sort | Korbecki, Jan |
collection | PubMed |
description | A neoplastic tumor consists of cancer cells that interact with each other and non-cancerous cells that support the development of the cancer. One such cell are tumor-associated macrophages (TAMs). These cells secrete many chemokines into the tumor microenvironment, including especially a large amount of CCL18. This chemokine is a marker of the M2 macrophage subset; this is the reason why an increase in the production of CCL18 is associated with the immunosuppressive nature of the tumor microenvironment and an important element of cancer immune evasion. Consequently, elevated levels of CCL18 in the serum and the tumor are connected with a worse prognosis for the patient. This paper shows the importance of CCL18 in neoplastic processes. It includes a description of the signal transduction from PITPNM3 in CCL18-dependent migration, invasion, and epithelial-to-mesenchymal transition (EMT) cancer cells. The importance of CCL18 in angiogenesis has also been described. The paper also describes the effect of CCL18 on the recruitment to the cancer niche and the functioning of cells such as TAMs, regulatory T cells (T(reg)), cancer-associated fibroblasts (CAFs) and tumor-associated dendritic cells (TADCs). The last part of the paper describes the possibility of using CCL18 as a therapeutic target during anti-cancer therapy. |
format | Online Article Text |
id | pubmed-7663205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76632052020-11-14 CCL18 in the Progression of Cancer Korbecki, Jan Olbromski, Mateusz Dzięgiel, Piotr Int J Mol Sci Review A neoplastic tumor consists of cancer cells that interact with each other and non-cancerous cells that support the development of the cancer. One such cell are tumor-associated macrophages (TAMs). These cells secrete many chemokines into the tumor microenvironment, including especially a large amount of CCL18. This chemokine is a marker of the M2 macrophage subset; this is the reason why an increase in the production of CCL18 is associated with the immunosuppressive nature of the tumor microenvironment and an important element of cancer immune evasion. Consequently, elevated levels of CCL18 in the serum and the tumor are connected with a worse prognosis for the patient. This paper shows the importance of CCL18 in neoplastic processes. It includes a description of the signal transduction from PITPNM3 in CCL18-dependent migration, invasion, and epithelial-to-mesenchymal transition (EMT) cancer cells. The importance of CCL18 in angiogenesis has also been described. The paper also describes the effect of CCL18 on the recruitment to the cancer niche and the functioning of cells such as TAMs, regulatory T cells (T(reg)), cancer-associated fibroblasts (CAFs) and tumor-associated dendritic cells (TADCs). The last part of the paper describes the possibility of using CCL18 as a therapeutic target during anti-cancer therapy. MDPI 2020-10-26 /pmc/articles/PMC7663205/ /pubmed/33114763 http://dx.doi.org/10.3390/ijms21217955 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Korbecki, Jan Olbromski, Mateusz Dzięgiel, Piotr CCL18 in the Progression of Cancer |
title | CCL18 in the Progression of Cancer |
title_full | CCL18 in the Progression of Cancer |
title_fullStr | CCL18 in the Progression of Cancer |
title_full_unstemmed | CCL18 in the Progression of Cancer |
title_short | CCL18 in the Progression of Cancer |
title_sort | ccl18 in the progression of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663205/ https://www.ncbi.nlm.nih.gov/pubmed/33114763 http://dx.doi.org/10.3390/ijms21217955 |
work_keys_str_mv | AT korbeckijan ccl18intheprogressionofcancer AT olbromskimateusz ccl18intheprogressionofcancer AT dziegielpiotr ccl18intheprogressionofcancer |