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Biological and Pharmacological Effects of Synthetic Saponins

Saponins are amphiphilic molecules consisting of carbohydrate and either triterpenoid or steroid aglycone moieties and are noted for their multiple biological activities—Fungicidal, antimicrobial, antiviral, anti-inflammatory, anticancer, antioxidant and immunomodulatory effects have all been observ...

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Detalles Bibliográficos
Autores principales: Juang, Yu-Pu, Liang, Pi-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663351/
https://www.ncbi.nlm.nih.gov/pubmed/33121124
http://dx.doi.org/10.3390/molecules25214974
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author Juang, Yu-Pu
Liang, Pi-Hui
author_facet Juang, Yu-Pu
Liang, Pi-Hui
author_sort Juang, Yu-Pu
collection PubMed
description Saponins are amphiphilic molecules consisting of carbohydrate and either triterpenoid or steroid aglycone moieties and are noted for their multiple biological activities—Fungicidal, antimicrobial, antiviral, anti-inflammatory, anticancer, antioxidant and immunomodulatory effects have all been observed. Saponins from natural sources have long been used in herbal and traditional medicines; however, the isolation of complexed saponins from nature is difficult and laborious, due to the scarce amount and structure heterogeneity. Chemical synthesis is considered a powerful tool to expand the structural diversity of saponin, leading to the discovery of promising compounds. This review focuses on recent developments in the structure optimization and biological evaluation of synthetic triterpenoid and steroid saponin derivatives. By summarizing the structure–activity relationship (SAR) results, we hope to provide the direction for future development of saponin-based bioactive compounds.
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spelling pubmed-76633512020-11-14 Biological and Pharmacological Effects of Synthetic Saponins Juang, Yu-Pu Liang, Pi-Hui Molecules Review Saponins are amphiphilic molecules consisting of carbohydrate and either triterpenoid or steroid aglycone moieties and are noted for their multiple biological activities—Fungicidal, antimicrobial, antiviral, anti-inflammatory, anticancer, antioxidant and immunomodulatory effects have all been observed. Saponins from natural sources have long been used in herbal and traditional medicines; however, the isolation of complexed saponins from nature is difficult and laborious, due to the scarce amount and structure heterogeneity. Chemical synthesis is considered a powerful tool to expand the structural diversity of saponin, leading to the discovery of promising compounds. This review focuses on recent developments in the structure optimization and biological evaluation of synthetic triterpenoid and steroid saponin derivatives. By summarizing the structure–activity relationship (SAR) results, we hope to provide the direction for future development of saponin-based bioactive compounds. MDPI 2020-10-27 /pmc/articles/PMC7663351/ /pubmed/33121124 http://dx.doi.org/10.3390/molecules25214974 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Juang, Yu-Pu
Liang, Pi-Hui
Biological and Pharmacological Effects of Synthetic Saponins
title Biological and Pharmacological Effects of Synthetic Saponins
title_full Biological and Pharmacological Effects of Synthetic Saponins
title_fullStr Biological and Pharmacological Effects of Synthetic Saponins
title_full_unstemmed Biological and Pharmacological Effects of Synthetic Saponins
title_short Biological and Pharmacological Effects of Synthetic Saponins
title_sort biological and pharmacological effects of synthetic saponins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663351/
https://www.ncbi.nlm.nih.gov/pubmed/33121124
http://dx.doi.org/10.3390/molecules25214974
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