Cargando…

Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material

The Bio-C Sealer is a recently developed high-plasticity, calcium-silicate-based, ready-to-use material. In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR)....

Descripción completa

Detalles Bibliográficos
Autores principales: Okamura, Tomoharu, Chen, Liji, Tsumano, Nobuhito, Ikeda, Chihoko, Komasa, Satoshi, Tominaga, Kazuya, Hashimoto, Yoshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663406/
https://www.ncbi.nlm.nih.gov/pubmed/33114595
http://dx.doi.org/10.3390/ma13214770
_version_ 1783609620597571584
author Okamura, Tomoharu
Chen, Liji
Tsumano, Nobuhito
Ikeda, Chihoko
Komasa, Satoshi
Tominaga, Kazuya
Hashimoto, Yoshiya
author_facet Okamura, Tomoharu
Chen, Liji
Tsumano, Nobuhito
Ikeda, Chihoko
Komasa, Satoshi
Tominaga, Kazuya
Hashimoto, Yoshiya
author_sort Okamura, Tomoharu
collection PubMed
description The Bio-C Sealer is a recently developed high-plasticity, calcium-silicate-based, ready-to-use material. In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of the Bio-C Sealer was investigated using cytotoxicity tests and histological responses in the roots of dogs’ teeth. XRD, SEM, and FTIR produced hydrated calcium silicate in the presence of water molecules. In addition, FTIR showed the formation of calcium hydroxide and polyethylene glycol, a dispersing agent. The 1:4 dilutions of Bio-C Sealer presented weaker cytotoxicity than the Calcipex II in an in vitro system using the V-79 cell line. After 90 d, the periradicular tissue response of beagle dog roots was histologically evaluated. Absence of periradicular inflammation was reported in 17 of the 18 roots assessed with the Bio-C Sealer, whereas mature vertical periodontal ligament fibers were observed in the apical root ends filled with the Bio-C Sealer. Based on these results and previous investigations, the Bio-C Sealer is recommended as an effective root-end filling material. These results are relevant for clinicians considering the use of Bio-C Sealer for treating their patients.
format Online
Article
Text
id pubmed-7663406
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76634062020-11-14 Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material Okamura, Tomoharu Chen, Liji Tsumano, Nobuhito Ikeda, Chihoko Komasa, Satoshi Tominaga, Kazuya Hashimoto, Yoshiya Materials (Basel) Article The Bio-C Sealer is a recently developed high-plasticity, calcium-silicate-based, ready-to-use material. In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of the Bio-C Sealer was investigated using cytotoxicity tests and histological responses in the roots of dogs’ teeth. XRD, SEM, and FTIR produced hydrated calcium silicate in the presence of water molecules. In addition, FTIR showed the formation of calcium hydroxide and polyethylene glycol, a dispersing agent. The 1:4 dilutions of Bio-C Sealer presented weaker cytotoxicity than the Calcipex II in an in vitro system using the V-79 cell line. After 90 d, the periradicular tissue response of beagle dog roots was histologically evaluated. Absence of periradicular inflammation was reported in 17 of the 18 roots assessed with the Bio-C Sealer, whereas mature vertical periodontal ligament fibers were observed in the apical root ends filled with the Bio-C Sealer. Based on these results and previous investigations, the Bio-C Sealer is recommended as an effective root-end filling material. These results are relevant for clinicians considering the use of Bio-C Sealer for treating their patients. MDPI 2020-10-26 /pmc/articles/PMC7663406/ /pubmed/33114595 http://dx.doi.org/10.3390/ma13214770 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Okamura, Tomoharu
Chen, Liji
Tsumano, Nobuhito
Ikeda, Chihoko
Komasa, Satoshi
Tominaga, Kazuya
Hashimoto, Yoshiya
Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material
title Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material
title_full Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material
title_fullStr Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material
title_full_unstemmed Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material
title_short Biocompatibility of a High-Plasticity, Calcium Silicate-Based, Ready-to-Use Material
title_sort biocompatibility of a high-plasticity, calcium silicate-based, ready-to-use material
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663406/
https://www.ncbi.nlm.nih.gov/pubmed/33114595
http://dx.doi.org/10.3390/ma13214770
work_keys_str_mv AT okamuratomoharu biocompatibilityofahighplasticitycalciumsilicatebasedreadytousematerial
AT chenliji biocompatibilityofahighplasticitycalciumsilicatebasedreadytousematerial
AT tsumanonobuhito biocompatibilityofahighplasticitycalciumsilicatebasedreadytousematerial
AT ikedachihoko biocompatibilityofahighplasticitycalciumsilicatebasedreadytousematerial
AT komasasatoshi biocompatibilityofahighplasticitycalciumsilicatebasedreadytousematerial
AT tominagakazuya biocompatibilityofahighplasticitycalciumsilicatebasedreadytousematerial
AT hashimotoyoshiya biocompatibilityofahighplasticitycalciumsilicatebasedreadytousematerial