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Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study

Hyperbaric oxygen therapy (HBOT) has been used to provide oxygen to underperfused organs following ischemia or carbon monoxide intoxication. Various beneficial consequences of HBOT have been reported, including wound healing, anti-inflammatory action, and cell survival; however, the molecular mechan...

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Autores principales: Chang, Jae Seung, Chang, Eunha, Lee, Yoonsuk, Cha, Yong Sung, Cha, Seung-Kuy, Cho, Won Gil, Jeong, Yangsik, Kim, Hyun, Park, Kyu-Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663415/
https://www.ncbi.nlm.nih.gov/pubmed/33120884
http://dx.doi.org/10.3390/ijerph17217853
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author Chang, Jae Seung
Chang, Eunha
Lee, Yoonsuk
Cha, Yong Sung
Cha, Seung-Kuy
Cho, Won Gil
Jeong, Yangsik
Kim, Hyun
Park, Kyu-Sang
author_facet Chang, Jae Seung
Chang, Eunha
Lee, Yoonsuk
Cha, Yong Sung
Cha, Seung-Kuy
Cho, Won Gil
Jeong, Yangsik
Kim, Hyun
Park, Kyu-Sang
author_sort Chang, Jae Seung
collection PubMed
description Hyperbaric oxygen therapy (HBOT) has been used to provide oxygen to underperfused organs following ischemia or carbon monoxide intoxication. Various beneficial consequences of HBOT have been reported, including wound healing, anti-inflammatory action, and cell survival; however, the molecular mechanisms underlying these effects have not been elucidated yet. We applied a single HBOT program consisting of administration of 2.8 atmospheres absolute (ATA) for 45 min, followed by 2.0 ATA for 55 min, to 10 male volunteers without any metabolic disease. Within 1 week of HBOT, there was no alteration in serum biochemical variables, except for an increase in triglyceride content. As a mitochondrial stress indicator, the serum concentration of growth differentiation factor 15 was reduced by HBOT. The circulating level of γ–glutamyltransferase was also decreased by HBOT, suggesting an attenuation of oxidative stress. HBOT increased adiponectin and reduced leptin levels in the serum, leading to an elevated adiponectin/leptin ratio. This is the first study to investigate the effect of HBOT on serum levels of metabolic stress-related biomarkers. We suggest that HBOT attenuates mitochondrial and oxidative stresses, and relieves metabolic burdens, indicating its potential for use in therapeutic applications to metabolic diseases.
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spelling pubmed-76634152020-11-14 Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study Chang, Jae Seung Chang, Eunha Lee, Yoonsuk Cha, Yong Sung Cha, Seung-Kuy Cho, Won Gil Jeong, Yangsik Kim, Hyun Park, Kyu-Sang Int J Environ Res Public Health Article Hyperbaric oxygen therapy (HBOT) has been used to provide oxygen to underperfused organs following ischemia or carbon monoxide intoxication. Various beneficial consequences of HBOT have been reported, including wound healing, anti-inflammatory action, and cell survival; however, the molecular mechanisms underlying these effects have not been elucidated yet. We applied a single HBOT program consisting of administration of 2.8 atmospheres absolute (ATA) for 45 min, followed by 2.0 ATA for 55 min, to 10 male volunteers without any metabolic disease. Within 1 week of HBOT, there was no alteration in serum biochemical variables, except for an increase in triglyceride content. As a mitochondrial stress indicator, the serum concentration of growth differentiation factor 15 was reduced by HBOT. The circulating level of γ–glutamyltransferase was also decreased by HBOT, suggesting an attenuation of oxidative stress. HBOT increased adiponectin and reduced leptin levels in the serum, leading to an elevated adiponectin/leptin ratio. This is the first study to investigate the effect of HBOT on serum levels of metabolic stress-related biomarkers. We suggest that HBOT attenuates mitochondrial and oxidative stresses, and relieves metabolic burdens, indicating its potential for use in therapeutic applications to metabolic diseases. MDPI 2020-10-27 2020-11 /pmc/articles/PMC7663415/ /pubmed/33120884 http://dx.doi.org/10.3390/ijerph17217853 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Jae Seung
Chang, Eunha
Lee, Yoonsuk
Cha, Yong Sung
Cha, Seung-Kuy
Cho, Won Gil
Jeong, Yangsik
Kim, Hyun
Park, Kyu-Sang
Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study
title Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study
title_full Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study
title_fullStr Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study
title_full_unstemmed Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study
title_short Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study
title_sort hyperbaric oxygen exposure attenuates circulating stress biomarkers: a pilot interventional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663415/
https://www.ncbi.nlm.nih.gov/pubmed/33120884
http://dx.doi.org/10.3390/ijerph17217853
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