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Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
Spanning from the mitochondria’s outer surface to the inner membrane, the nuclear-encoded protein ATAD3A maintains vital roles in regulating mitochondrial dynamics, homeostasis, metabolism, and interactions with the endoplasmic reticulum. Recently, elevated levels of ATAD3A have been reported in sev...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663417/ https://www.ncbi.nlm.nih.gov/pubmed/33113782 http://dx.doi.org/10.3390/ijms21217917 |
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author | Lang, Liwei Loveless, Reid Teng, Yong |
author_facet | Lang, Liwei Loveless, Reid Teng, Yong |
author_sort | Lang, Liwei |
collection | PubMed |
description | Spanning from the mitochondria’s outer surface to the inner membrane, the nuclear-encoded protein ATAD3A maintains vital roles in regulating mitochondrial dynamics, homeostasis, metabolism, and interactions with the endoplasmic reticulum. Recently, elevated levels of ATAD3A have been reported in several types of cancer and to be tightly correlated with cancer development and progression, including increased cancer cell potential of proliferation, metastasis, and resistance to chemotherapy and radiotherapy. In the current review, we reveal ATAD3A as the link between mitochondrial functions and cancer biology and the accumulating evidence presenting ATAD3A as an attractive target for the development of novel cancer therapy to inhibit aberrant cancer metabolism and progression. |
format | Online Article Text |
id | pubmed-7663417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76634172020-11-14 Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer Lang, Liwei Loveless, Reid Teng, Yong Int J Mol Sci Review Spanning from the mitochondria’s outer surface to the inner membrane, the nuclear-encoded protein ATAD3A maintains vital roles in regulating mitochondrial dynamics, homeostasis, metabolism, and interactions with the endoplasmic reticulum. Recently, elevated levels of ATAD3A have been reported in several types of cancer and to be tightly correlated with cancer development and progression, including increased cancer cell potential of proliferation, metastasis, and resistance to chemotherapy and radiotherapy. In the current review, we reveal ATAD3A as the link between mitochondrial functions and cancer biology and the accumulating evidence presenting ATAD3A as an attractive target for the development of novel cancer therapy to inhibit aberrant cancer metabolism and progression. MDPI 2020-10-25 /pmc/articles/PMC7663417/ /pubmed/33113782 http://dx.doi.org/10.3390/ijms21217917 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lang, Liwei Loveless, Reid Teng, Yong Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer |
title | Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer |
title_full | Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer |
title_fullStr | Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer |
title_full_unstemmed | Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer |
title_short | Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer |
title_sort | emerging links between control of mitochondrial protein atad3a and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663417/ https://www.ncbi.nlm.nih.gov/pubmed/33113782 http://dx.doi.org/10.3390/ijms21217917 |
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