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Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer

Spanning from the mitochondria’s outer surface to the inner membrane, the nuclear-encoded protein ATAD3A maintains vital roles in regulating mitochondrial dynamics, homeostasis, metabolism, and interactions with the endoplasmic reticulum. Recently, elevated levels of ATAD3A have been reported in sev...

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Detalles Bibliográficos
Autores principales: Lang, Liwei, Loveless, Reid, Teng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663417/
https://www.ncbi.nlm.nih.gov/pubmed/33113782
http://dx.doi.org/10.3390/ijms21217917
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author Lang, Liwei
Loveless, Reid
Teng, Yong
author_facet Lang, Liwei
Loveless, Reid
Teng, Yong
author_sort Lang, Liwei
collection PubMed
description Spanning from the mitochondria’s outer surface to the inner membrane, the nuclear-encoded protein ATAD3A maintains vital roles in regulating mitochondrial dynamics, homeostasis, metabolism, and interactions with the endoplasmic reticulum. Recently, elevated levels of ATAD3A have been reported in several types of cancer and to be tightly correlated with cancer development and progression, including increased cancer cell potential of proliferation, metastasis, and resistance to chemotherapy and radiotherapy. In the current review, we reveal ATAD3A as the link between mitochondrial functions and cancer biology and the accumulating evidence presenting ATAD3A as an attractive target for the development of novel cancer therapy to inhibit aberrant cancer metabolism and progression.
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spelling pubmed-76634172020-11-14 Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer Lang, Liwei Loveless, Reid Teng, Yong Int J Mol Sci Review Spanning from the mitochondria’s outer surface to the inner membrane, the nuclear-encoded protein ATAD3A maintains vital roles in regulating mitochondrial dynamics, homeostasis, metabolism, and interactions with the endoplasmic reticulum. Recently, elevated levels of ATAD3A have been reported in several types of cancer and to be tightly correlated with cancer development and progression, including increased cancer cell potential of proliferation, metastasis, and resistance to chemotherapy and radiotherapy. In the current review, we reveal ATAD3A as the link between mitochondrial functions and cancer biology and the accumulating evidence presenting ATAD3A as an attractive target for the development of novel cancer therapy to inhibit aberrant cancer metabolism and progression. MDPI 2020-10-25 /pmc/articles/PMC7663417/ /pubmed/33113782 http://dx.doi.org/10.3390/ijms21217917 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lang, Liwei
Loveless, Reid
Teng, Yong
Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
title Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
title_full Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
title_fullStr Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
title_full_unstemmed Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
title_short Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
title_sort emerging links between control of mitochondrial protein atad3a and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663417/
https://www.ncbi.nlm.nih.gov/pubmed/33113782
http://dx.doi.org/10.3390/ijms21217917
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