Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis

We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a hetero Diels–Alder. The obtained furopyran deri...

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Detalles Bibliográficos
Autores principales: Ruch, Marie, Brach, Nicolas, Galéa, Roméric, Wagner, Patrick, Blond, Gaëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663467/
https://www.ncbi.nlm.nih.gov/pubmed/33121149
http://dx.doi.org/10.3390/molecules25214976
Descripción
Sumario:We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a hetero Diels–Alder. The obtained furopyran derivatives contain fused and spiro-heterocycles. During this one-pot process, four bonds and four controlled stereogenic centers including a quaternary center are formed.

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