The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?

Endometriosis is defined as the presence of endometrial foci, localized beyond their primary site, i.e., the uterine cavity. The etiology of this disease is rather complex. Its development is supported by hormonal, immunological, and environmental factors. During recent years, particular attention h...

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Autores principales: Smolarz, Beata, Szyłło, Krzysztof, Romanowicz, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663510/
https://www.ncbi.nlm.nih.gov/pubmed/33153202
http://dx.doi.org/10.3390/ijms21218235
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author Smolarz, Beata
Szyłło, Krzysztof
Romanowicz, Hanna
author_facet Smolarz, Beata
Szyłło, Krzysztof
Romanowicz, Hanna
author_sort Smolarz, Beata
collection PubMed
description Endometriosis is defined as the presence of endometrial foci, localized beyond their primary site, i.e., the uterine cavity. The etiology of this disease is rather complex. Its development is supported by hormonal, immunological, and environmental factors. During recent years, particular attention has been focused on the genetic mechanisms that may be of particular significance for the increased incidence rates of endometriosis. According to most recent studies, ESR2 and CYP19A1 genes may account for the potential risk factors of infertility associated with endometriosis. The paper presents a thorough review of the latest reports and data concerning the genetic background of the risk for endometriosis development.
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spelling pubmed-76635102020-11-14 The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development? Smolarz, Beata Szyłło, Krzysztof Romanowicz, Hanna Int J Mol Sci Review Endometriosis is defined as the presence of endometrial foci, localized beyond their primary site, i.e., the uterine cavity. The etiology of this disease is rather complex. Its development is supported by hormonal, immunological, and environmental factors. During recent years, particular attention has been focused on the genetic mechanisms that may be of particular significance for the increased incidence rates of endometriosis. According to most recent studies, ESR2 and CYP19A1 genes may account for the potential risk factors of infertility associated with endometriosis. The paper presents a thorough review of the latest reports and data concerning the genetic background of the risk for endometriosis development. MDPI 2020-11-03 /pmc/articles/PMC7663510/ /pubmed/33153202 http://dx.doi.org/10.3390/ijms21218235 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Smolarz, Beata
Szyłło, Krzysztof
Romanowicz, Hanna
The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?
title The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?
title_full The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?
title_fullStr The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?
title_full_unstemmed The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?
title_short The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?
title_sort genetic background of endometriosis: can esr2 and cyp19a1 genes be a potential risk factor for its development?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663510/
https://www.ncbi.nlm.nih.gov/pubmed/33153202
http://dx.doi.org/10.3390/ijms21218235
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