Cargando…
Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs
The circadian rhythms are an intrinsic timekeeping system that regulates numerous physiological, biochemical, and behavioral processes at intervals of approximately 24 h. By regulating such processes, the circadian rhythm allows organisms to anticipate and adapt to continuously changing environmenta...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663518/ https://www.ncbi.nlm.nih.gov/pubmed/33114496 http://dx.doi.org/10.3390/molecules25214937 |
_version_ | 1783609645336625152 |
---|---|
author | Rahman, Sadia Wittine, Karlo Sedić, Mirela Markova-Car, Elitza P. |
author_facet | Rahman, Sadia Wittine, Karlo Sedić, Mirela Markova-Car, Elitza P. |
author_sort | Rahman, Sadia |
collection | PubMed |
description | The circadian rhythms are an intrinsic timekeeping system that regulates numerous physiological, biochemical, and behavioral processes at intervals of approximately 24 h. By regulating such processes, the circadian rhythm allows organisms to anticipate and adapt to continuously changing environmental conditions. A growing body of evidence shows that disruptions to the circadian rhythm can lead to various disorders, including cancer. Recently, crucial knowledge has arisen regarding the essential features that underlie the overt circadian rhythm and its influence on physiological outputs. This knowledge suggests that specific small molecules can be utilized to control the circadian rhythm. It has been discovered that these small molecules can regulate circadian-clock-related disorders such as metabolic, cardiovascular, inflammatory, as well as cancer. This review examines the potential use of small molecules for developing new drugs, with emphasis placed on recent progress that has been made regarding the identification of small-molecule clock modulators and their potential use in treating cancer. |
format | Online Article Text |
id | pubmed-7663518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76635182020-11-14 Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs Rahman, Sadia Wittine, Karlo Sedić, Mirela Markova-Car, Elitza P. Molecules Review The circadian rhythms are an intrinsic timekeeping system that regulates numerous physiological, biochemical, and behavioral processes at intervals of approximately 24 h. By regulating such processes, the circadian rhythm allows organisms to anticipate and adapt to continuously changing environmental conditions. A growing body of evidence shows that disruptions to the circadian rhythm can lead to various disorders, including cancer. Recently, crucial knowledge has arisen regarding the essential features that underlie the overt circadian rhythm and its influence on physiological outputs. This knowledge suggests that specific small molecules can be utilized to control the circadian rhythm. It has been discovered that these small molecules can regulate circadian-clock-related disorders such as metabolic, cardiovascular, inflammatory, as well as cancer. This review examines the potential use of small molecules for developing new drugs, with emphasis placed on recent progress that has been made regarding the identification of small-molecule clock modulators and their potential use in treating cancer. MDPI 2020-10-26 /pmc/articles/PMC7663518/ /pubmed/33114496 http://dx.doi.org/10.3390/molecules25214937 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rahman, Sadia Wittine, Karlo Sedić, Mirela Markova-Car, Elitza P. Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs |
title | Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs |
title_full | Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs |
title_fullStr | Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs |
title_full_unstemmed | Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs |
title_short | Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs |
title_sort | small molecules targeting biological clock; a novel prospective for anti-cancer drugs |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663518/ https://www.ncbi.nlm.nih.gov/pubmed/33114496 http://dx.doi.org/10.3390/molecules25214937 |
work_keys_str_mv | AT rahmansadia smallmoleculestargetingbiologicalclockanovelprospectiveforanticancerdrugs AT wittinekarlo smallmoleculestargetingbiologicalclockanovelprospectiveforanticancerdrugs AT sedicmirela smallmoleculestargetingbiologicalclockanovelprospectiveforanticancerdrugs AT markovacarelitzap smallmoleculestargetingbiologicalclockanovelprospectiveforanticancerdrugs |