Cargando…
Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease
Systemic presence of arthritis autoantibodies (AAb) is specific for rheumatoid arthritis (RA). AAb initiation might be triggered by chronic mucosal inflammation, such as in inflammatory bowel disease (IBD). We assessed the prevalence of anti-citrullinated protein antibodies (ACPA) and rheumatoid fac...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663588/ https://www.ncbi.nlm.nih.gov/pubmed/33139618 http://dx.doi.org/10.3390/ijerph17218054 |
_version_ | 1783609661899931648 |
---|---|
author | Janssen, Koen M. J. Hop, Hilde Vissink, Arjan Dijkstra, Gerard de Smit, Menke J. Brouwer, Elisabeth Westra, Johanna |
author_facet | Janssen, Koen M. J. Hop, Hilde Vissink, Arjan Dijkstra, Gerard de Smit, Menke J. Brouwer, Elisabeth Westra, Johanna |
author_sort | Janssen, Koen M. J. |
collection | PubMed |
description | Systemic presence of arthritis autoantibodies (AAb) is specific for rheumatoid arthritis (RA). AAb initiation might be triggered by chronic mucosal inflammation, such as in inflammatory bowel disease (IBD). We assessed the prevalence of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) in ulcerative colitis (UC) and Crohn’s disease (CD) patients, with regard to the prevalence of joint complaints in AAb+ versus AAb− IBD patients. RA patients and healthy subjects (HC) served as controls. Serum was collected from 226 UC, 165 CD and 86 RA patients, and 36 HCs. One-hundred-and-ten UC (48.7%) and 76 CD (46.1%) patients were seropositive for at least one autoantibody, compared to 4 (13.9%) HCs and 81 (94.2%) RA patients. Eighty-three (37%) UC and 52 (32%) CD patients were seropositive for the anti-cyclic citrullinated protein antibody (anti-CCP2) of the immunoglobulin A type (IgA anti-CCP2), compared to 1 (2.8%) HC and 64 (74%) RA patients. RF of the immunoglobulin G type (IgG RF) and IgA RF seropositivity in UC and CD patients was comparable to HCs and low compared to RA patients. Arthralgia was reported by 34 (18.7%) UC and 50 (33.1%) CD patients, but presence of arthralgia was not increased in AAb+ patients. AAbs are frequently present in IBD patients, supporting the hypothesis that inflammation of intestinal mucosa induces low systemic levels of ACPA. |
format | Online Article Text |
id | pubmed-7663588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76635882020-11-14 Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease Janssen, Koen M. J. Hop, Hilde Vissink, Arjan Dijkstra, Gerard de Smit, Menke J. Brouwer, Elisabeth Westra, Johanna Int J Environ Res Public Health Article Systemic presence of arthritis autoantibodies (AAb) is specific for rheumatoid arthritis (RA). AAb initiation might be triggered by chronic mucosal inflammation, such as in inflammatory bowel disease (IBD). We assessed the prevalence of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) in ulcerative colitis (UC) and Crohn’s disease (CD) patients, with regard to the prevalence of joint complaints in AAb+ versus AAb− IBD patients. RA patients and healthy subjects (HC) served as controls. Serum was collected from 226 UC, 165 CD and 86 RA patients, and 36 HCs. One-hundred-and-ten UC (48.7%) and 76 CD (46.1%) patients were seropositive for at least one autoantibody, compared to 4 (13.9%) HCs and 81 (94.2%) RA patients. Eighty-three (37%) UC and 52 (32%) CD patients were seropositive for the anti-cyclic citrullinated protein antibody (anti-CCP2) of the immunoglobulin A type (IgA anti-CCP2), compared to 1 (2.8%) HC and 64 (74%) RA patients. RF of the immunoglobulin G type (IgG RF) and IgA RF seropositivity in UC and CD patients was comparable to HCs and low compared to RA patients. Arthralgia was reported by 34 (18.7%) UC and 50 (33.1%) CD patients, but presence of arthralgia was not increased in AAb+ patients. AAbs are frequently present in IBD patients, supporting the hypothesis that inflammation of intestinal mucosa induces low systemic levels of ACPA. MDPI 2020-11-01 2020-11 /pmc/articles/PMC7663588/ /pubmed/33139618 http://dx.doi.org/10.3390/ijerph17218054 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Janssen, Koen M. J. Hop, Hilde Vissink, Arjan Dijkstra, Gerard de Smit, Menke J. Brouwer, Elisabeth Westra, Johanna Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease |
title | Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease |
title_full | Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease |
title_fullStr | Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease |
title_full_unstemmed | Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease |
title_short | Levels of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor, Including IgA Isotypes, and Articular Manifestations in Ulcerative Colitis and Crohn’s Disease |
title_sort | levels of anti-citrullinated protein antibodies and rheumatoid factor, including iga isotypes, and articular manifestations in ulcerative colitis and crohn’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663588/ https://www.ncbi.nlm.nih.gov/pubmed/33139618 http://dx.doi.org/10.3390/ijerph17218054 |
work_keys_str_mv | AT janssenkoenmj levelsofanticitrullinatedproteinantibodiesandrheumatoidfactorincludingigaisotypesandarticularmanifestationsinulcerativecolitisandcrohnsdisease AT hophilde levelsofanticitrullinatedproteinantibodiesandrheumatoidfactorincludingigaisotypesandarticularmanifestationsinulcerativecolitisandcrohnsdisease AT vissinkarjan levelsofanticitrullinatedproteinantibodiesandrheumatoidfactorincludingigaisotypesandarticularmanifestationsinulcerativecolitisandcrohnsdisease AT dijkstragerard levelsofanticitrullinatedproteinantibodiesandrheumatoidfactorincludingigaisotypesandarticularmanifestationsinulcerativecolitisandcrohnsdisease AT desmitmenkej levelsofanticitrullinatedproteinantibodiesandrheumatoidfactorincludingigaisotypesandarticularmanifestationsinulcerativecolitisandcrohnsdisease AT brouwerelisabeth levelsofanticitrullinatedproteinantibodiesandrheumatoidfactorincludingigaisotypesandarticularmanifestationsinulcerativecolitisandcrohnsdisease AT westrajohanna levelsofanticitrullinatedproteinantibodiesandrheumatoidfactorincludingigaisotypesandarticularmanifestationsinulcerativecolitisandcrohnsdisease |