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Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors

This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sect...

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Autores principales: Naranjo, Cristina, Dueñas, María, Barrera, Carlos, Moratalla, Guillermo, Failde, Inmaculada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663768/
https://www.ncbi.nlm.nih.gov/pubmed/33153196
http://dx.doi.org/10.3390/ijerph17218125
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author Naranjo, Cristina
Dueñas, María
Barrera, Carlos
Moratalla, Guillermo
Failde, Inmaculada
author_facet Naranjo, Cristina
Dueñas, María
Barrera, Carlos
Moratalla, Guillermo
Failde, Inmaculada
author_sort Naranjo, Cristina
collection PubMed
description This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sectional study was performed in patients with type-2 diabetes mellitus and neuropathy. Patients were classified into two groups—with or without neuropathic pain—according to the “Douleur Neuropathique-4 (DN4)” scale. Sleep characteristics and quality (Medical Outcomes Study—MOS-sleep), pain phenotype (Neuropathic Pain Symptom Inventory—NPSI), mood status (Hospital Anxiety and Depression scale—HADS), pain intensity (Visual Analogue Scale—VAS), and quality of life (SF-12v2) were measured. The sample included 130 patients (65 with DNP). The mean scores in all the dimensions of the MOS-sleep scale were higher (more disturbances) in the DNP patients. Higher scores in anxiety or depression, greater intensity of pain or a higher score in the paroxysmal pain phenotype were associated with lower sleep quality in DNP patients. A shorter duration of the diabetes and lower levels of glycated hemoglobin were also associated with lower sleep quality. The results show the relationship between DNP and sleep quality, and the importance of assessing sensory phenotypes and mental comorbidities in these patients. Taking these factors into consideration, to adopt a multimodal approach is necessary to achieve better clinical results.
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spelling pubmed-76637682020-11-14 Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors Naranjo, Cristina Dueñas, María Barrera, Carlos Moratalla, Guillermo Failde, Inmaculada Int J Environ Res Public Health Article This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sectional study was performed in patients with type-2 diabetes mellitus and neuropathy. Patients were classified into two groups—with or without neuropathic pain—according to the “Douleur Neuropathique-4 (DN4)” scale. Sleep characteristics and quality (Medical Outcomes Study—MOS-sleep), pain phenotype (Neuropathic Pain Symptom Inventory—NPSI), mood status (Hospital Anxiety and Depression scale—HADS), pain intensity (Visual Analogue Scale—VAS), and quality of life (SF-12v2) were measured. The sample included 130 patients (65 with DNP). The mean scores in all the dimensions of the MOS-sleep scale were higher (more disturbances) in the DNP patients. Higher scores in anxiety or depression, greater intensity of pain or a higher score in the paroxysmal pain phenotype were associated with lower sleep quality in DNP patients. A shorter duration of the diabetes and lower levels of glycated hemoglobin were also associated with lower sleep quality. The results show the relationship between DNP and sleep quality, and the importance of assessing sensory phenotypes and mental comorbidities in these patients. Taking these factors into consideration, to adopt a multimodal approach is necessary to achieve better clinical results. MDPI 2020-11-03 2020-11 /pmc/articles/PMC7663768/ /pubmed/33153196 http://dx.doi.org/10.3390/ijerph17218125 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Naranjo, Cristina
Dueñas, María
Barrera, Carlos
Moratalla, Guillermo
Failde, Inmaculada
Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors
title Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors
title_full Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors
title_fullStr Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors
title_full_unstemmed Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors
title_short Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors
title_sort sleep characteristics in diabetic patients depending on the occurrence of neuropathic pain and related factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663768/
https://www.ncbi.nlm.nih.gov/pubmed/33153196
http://dx.doi.org/10.3390/ijerph17218125
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