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Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663911/ https://www.ncbi.nlm.nih.gov/pubmed/33167426 http://dx.doi.org/10.3390/molecules25215147 |
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author | Hou, Wanting Liu, Ruiqi Bi, Siwei He, Qian Wang, Haibo Gu, Jun |
author_facet | Hou, Wanting Liu, Ruiqi Bi, Siwei He, Qian Wang, Haibo Gu, Jun |
author_sort | Hou, Wanting |
collection | PubMed |
description | Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy. |
format | Online Article Text |
id | pubmed-7663911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76639112020-11-14 Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications Hou, Wanting Liu, Ruiqi Bi, Siwei He, Qian Wang, Haibo Gu, Jun Molecules Article Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy. MDPI 2020-11-05 /pmc/articles/PMC7663911/ /pubmed/33167426 http://dx.doi.org/10.3390/molecules25215147 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hou, Wanting Liu, Ruiqi Bi, Siwei He, Qian Wang, Haibo Gu, Jun Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
title | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
title_full | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
title_fullStr | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
title_full_unstemmed | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
title_short | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
title_sort | photo-responsive polymersomes as drug delivery system for potential medical applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663911/ https://www.ncbi.nlm.nih.gov/pubmed/33167426 http://dx.doi.org/10.3390/molecules25215147 |
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