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Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pu...

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Autores principales: Hou, Wanting, Liu, Ruiqi, Bi, Siwei, He, Qian, Wang, Haibo, Gu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663911/
https://www.ncbi.nlm.nih.gov/pubmed/33167426
http://dx.doi.org/10.3390/molecules25215147
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author Hou, Wanting
Liu, Ruiqi
Bi, Siwei
He, Qian
Wang, Haibo
Gu, Jun
author_facet Hou, Wanting
Liu, Ruiqi
Bi, Siwei
He, Qian
Wang, Haibo
Gu, Jun
author_sort Hou, Wanting
collection PubMed
description Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.
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spelling pubmed-76639112020-11-14 Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications Hou, Wanting Liu, Ruiqi Bi, Siwei He, Qian Wang, Haibo Gu, Jun Molecules Article Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy. MDPI 2020-11-05 /pmc/articles/PMC7663911/ /pubmed/33167426 http://dx.doi.org/10.3390/molecules25215147 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hou, Wanting
Liu, Ruiqi
Bi, Siwei
He, Qian
Wang, Haibo
Gu, Jun
Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
title Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
title_full Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
title_fullStr Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
title_full_unstemmed Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
title_short Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
title_sort photo-responsive polymersomes as drug delivery system for potential medical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663911/
https://www.ncbi.nlm.nih.gov/pubmed/33167426
http://dx.doi.org/10.3390/molecules25215147
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