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Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms

Pani heloch (Antidesma montanum) is traditionally used to treat innumerable diseases and is a source of wild vegetables for the management of different pathological conditions. The present study explored the qualitative phytochemicals; quantitative phenol and flavonoid contents; in vitro antioxidant...

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Autores principales: Banu, Naureen, Alam, Najmul, Nazmul Islam, Mohammad, Islam, Sanjida, Sakib, Shahenur Alam, Hanif, Nujhat Binte, Chowdhury, Md. Riad, Tareq, Abu Montakim, Hasan Chowdhury, Kamrul, Jahan, Shamima, Azad, Afrina, Emran, Talha Bin, Simal-Gandara, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663931/
https://www.ncbi.nlm.nih.gov/pubmed/33167510
http://dx.doi.org/10.3390/molecules25215153
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author Banu, Naureen
Alam, Najmul
Nazmul Islam, Mohammad
Islam, Sanjida
Sakib, Shahenur Alam
Hanif, Nujhat Binte
Chowdhury, Md. Riad
Tareq, Abu Montakim
Hasan Chowdhury, Kamrul
Jahan, Shamima
Azad, Afrina
Emran, Talha Bin
Simal-Gandara, Jesus
author_facet Banu, Naureen
Alam, Najmul
Nazmul Islam, Mohammad
Islam, Sanjida
Sakib, Shahenur Alam
Hanif, Nujhat Binte
Chowdhury, Md. Riad
Tareq, Abu Montakim
Hasan Chowdhury, Kamrul
Jahan, Shamima
Azad, Afrina
Emran, Talha Bin
Simal-Gandara, Jesus
author_sort Banu, Naureen
collection PubMed
description Pani heloch (Antidesma montanum) is traditionally used to treat innumerable diseases and is a source of wild vegetables for the management of different pathological conditions. The present study explored the qualitative phytochemicals; quantitative phenol and flavonoid contents; in vitro antioxidant, anti-inflammatory, and thrombolytic effects; and in vivo antipyretic and analgesic properties of the methanol extract of A. montanum leaves in different experimental models. The extract exhibited secondary metabolites including alkaloids, flavonoids, flavanols, phytosterols, cholesterols, phenols, terpenoids, glycosides, fixed oils, emodines, coumarins, resins, and tannins. Besides, Pani heloch showed strong antioxidant activity (IC(50) = 99.00 µg/mL), while a moderate percentage of clot lysis (31.56%) in human blood and significant anti-inflammatory activity (p < 0.001) was achieved with the standard. Moreover, the analgesic and antipyretic properties appeared to trigger a significant response (p < 0.001) relative to in the control group. Besides, an in silico study of carpusin revealed favorable protein-binding affinities. Furthermore, the absorption, distribution, metabolism, excretion, and toxicity analysis and toxicological properties of all isolated compounds adopted Lipinski’s rule of five for drug-like potential and level of toxicity. Our research unveiled that the methanol extract of A. montanum leaves exhibited secondary metabolites that are a good source for managing inflammation, pyrexia, pain, and cellular toxicity. Computational approaches and further studies are required to identify the possible mechanism which responsible for the biological effects.
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spelling pubmed-76639312020-11-14 Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms Banu, Naureen Alam, Najmul Nazmul Islam, Mohammad Islam, Sanjida Sakib, Shahenur Alam Hanif, Nujhat Binte Chowdhury, Md. Riad Tareq, Abu Montakim Hasan Chowdhury, Kamrul Jahan, Shamima Azad, Afrina Emran, Talha Bin Simal-Gandara, Jesus Molecules Article Pani heloch (Antidesma montanum) is traditionally used to treat innumerable diseases and is a source of wild vegetables for the management of different pathological conditions. The present study explored the qualitative phytochemicals; quantitative phenol and flavonoid contents; in vitro antioxidant, anti-inflammatory, and thrombolytic effects; and in vivo antipyretic and analgesic properties of the methanol extract of A. montanum leaves in different experimental models. The extract exhibited secondary metabolites including alkaloids, flavonoids, flavanols, phytosterols, cholesterols, phenols, terpenoids, glycosides, fixed oils, emodines, coumarins, resins, and tannins. Besides, Pani heloch showed strong antioxidant activity (IC(50) = 99.00 µg/mL), while a moderate percentage of clot lysis (31.56%) in human blood and significant anti-inflammatory activity (p < 0.001) was achieved with the standard. Moreover, the analgesic and antipyretic properties appeared to trigger a significant response (p < 0.001) relative to in the control group. Besides, an in silico study of carpusin revealed favorable protein-binding affinities. Furthermore, the absorption, distribution, metabolism, excretion, and toxicity analysis and toxicological properties of all isolated compounds adopted Lipinski’s rule of five for drug-like potential and level of toxicity. Our research unveiled that the methanol extract of A. montanum leaves exhibited secondary metabolites that are a good source for managing inflammation, pyrexia, pain, and cellular toxicity. Computational approaches and further studies are required to identify the possible mechanism which responsible for the biological effects. MDPI 2020-11-05 /pmc/articles/PMC7663931/ /pubmed/33167510 http://dx.doi.org/10.3390/molecules25215153 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Banu, Naureen
Alam, Najmul
Nazmul Islam, Mohammad
Islam, Sanjida
Sakib, Shahenur Alam
Hanif, Nujhat Binte
Chowdhury, Md. Riad
Tareq, Abu Montakim
Hasan Chowdhury, Kamrul
Jahan, Shamima
Azad, Afrina
Emran, Talha Bin
Simal-Gandara, Jesus
Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms
title Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms
title_full Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms
title_fullStr Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms
title_full_unstemmed Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms
title_short Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms
title_sort insightful valorization of the biological activities of pani heloch leaves through experimental and computer-aided mechanisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663931/
https://www.ncbi.nlm.nih.gov/pubmed/33167510
http://dx.doi.org/10.3390/molecules25215153
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