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Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes

This short overview focuses on the causation and treatment of type 2 diabetes (T2D). Emphasis is given to the historical basis of understanding this disease and the background leading to emergence of the central role of insulin. The strengths of insulin administration in the treatment of diabetes ar...

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Autores principales: Bondy, Stephen C., Wu, Meixia, Prasad, Kedar N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663956/
https://www.ncbi.nlm.nih.gov/pubmed/33167495
http://dx.doi.org/10.3390/ijms21218302
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author Bondy, Stephen C.
Wu, Meixia
Prasad, Kedar N.
author_facet Bondy, Stephen C.
Wu, Meixia
Prasad, Kedar N.
author_sort Bondy, Stephen C.
collection PubMed
description This short overview focuses on the causation and treatment of type 2 diabetes (T2D). Emphasis is given to the historical basis of understanding this disease and the background leading to emergence of the central role of insulin. The strengths of insulin administration in the treatment of diabetes are profound, but these need to be balanced against several serious shortcomings of its extended use. Some alternative approaches to T2D management are considered. Insulin is no longer considered as the first choice for type 2 diabetes, and an expanding range of new therapeutic possibilities is emerging. While these may lack the potency of insulin, at a minimum, they allow a major reduction in the intensity of insulin use. In view of the rising worldwide incidence of this disease, it is imperative to develop safe and inexpensive means of limiting its potential for impairment of normal functioning.
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spelling pubmed-76639562020-11-14 Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes Bondy, Stephen C. Wu, Meixia Prasad, Kedar N. Int J Mol Sci Review This short overview focuses on the causation and treatment of type 2 diabetes (T2D). Emphasis is given to the historical basis of understanding this disease and the background leading to emergence of the central role of insulin. The strengths of insulin administration in the treatment of diabetes are profound, but these need to be balanced against several serious shortcomings of its extended use. Some alternative approaches to T2D management are considered. Insulin is no longer considered as the first choice for type 2 diabetes, and an expanding range of new therapeutic possibilities is emerging. While these may lack the potency of insulin, at a minimum, they allow a major reduction in the intensity of insulin use. In view of the rising worldwide incidence of this disease, it is imperative to develop safe and inexpensive means of limiting its potential for impairment of normal functioning. MDPI 2020-11-05 /pmc/articles/PMC7663956/ /pubmed/33167495 http://dx.doi.org/10.3390/ijms21218302 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bondy, Stephen C.
Wu, Meixia
Prasad, Kedar N.
Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes
title Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes
title_full Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes
title_fullStr Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes
title_full_unstemmed Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes
title_short Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes
title_sort alternatives to insulin for the regulation of blood sugar levels in type 2 diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663956/
https://www.ncbi.nlm.nih.gov/pubmed/33167495
http://dx.doi.org/10.3390/ijms21218302
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