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Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes
This short overview focuses on the causation and treatment of type 2 diabetes (T2D). Emphasis is given to the historical basis of understanding this disease and the background leading to emergence of the central role of insulin. The strengths of insulin administration in the treatment of diabetes ar...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663956/ https://www.ncbi.nlm.nih.gov/pubmed/33167495 http://dx.doi.org/10.3390/ijms21218302 |
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author | Bondy, Stephen C. Wu, Meixia Prasad, Kedar N. |
author_facet | Bondy, Stephen C. Wu, Meixia Prasad, Kedar N. |
author_sort | Bondy, Stephen C. |
collection | PubMed |
description | This short overview focuses on the causation and treatment of type 2 diabetes (T2D). Emphasis is given to the historical basis of understanding this disease and the background leading to emergence of the central role of insulin. The strengths of insulin administration in the treatment of diabetes are profound, but these need to be balanced against several serious shortcomings of its extended use. Some alternative approaches to T2D management are considered. Insulin is no longer considered as the first choice for type 2 diabetes, and an expanding range of new therapeutic possibilities is emerging. While these may lack the potency of insulin, at a minimum, they allow a major reduction in the intensity of insulin use. In view of the rising worldwide incidence of this disease, it is imperative to develop safe and inexpensive means of limiting its potential for impairment of normal functioning. |
format | Online Article Text |
id | pubmed-7663956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76639562020-11-14 Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes Bondy, Stephen C. Wu, Meixia Prasad, Kedar N. Int J Mol Sci Review This short overview focuses on the causation and treatment of type 2 diabetes (T2D). Emphasis is given to the historical basis of understanding this disease and the background leading to emergence of the central role of insulin. The strengths of insulin administration in the treatment of diabetes are profound, but these need to be balanced against several serious shortcomings of its extended use. Some alternative approaches to T2D management are considered. Insulin is no longer considered as the first choice for type 2 diabetes, and an expanding range of new therapeutic possibilities is emerging. While these may lack the potency of insulin, at a minimum, they allow a major reduction in the intensity of insulin use. In view of the rising worldwide incidence of this disease, it is imperative to develop safe and inexpensive means of limiting its potential for impairment of normal functioning. MDPI 2020-11-05 /pmc/articles/PMC7663956/ /pubmed/33167495 http://dx.doi.org/10.3390/ijms21218302 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bondy, Stephen C. Wu, Meixia Prasad, Kedar N. Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes |
title | Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes |
title_full | Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes |
title_fullStr | Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes |
title_full_unstemmed | Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes |
title_short | Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes |
title_sort | alternatives to insulin for the regulation of blood sugar levels in type 2 diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663956/ https://www.ncbi.nlm.nih.gov/pubmed/33167495 http://dx.doi.org/10.3390/ijms21218302 |
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