Cargando…

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

The kinetoplastids are protozoa characterized by the presence of a distinctive organelle, called the kinetoplast, which contains a large amount of DNA (kinetoplast DNA (kDNA)) inside their single mitochondrion. Kinetoplastids of medical and veterinary importance include Trypanosoma spp. (the causati...

Descripción completa

Detalles Bibliográficos
Autores principales: Ebiloma, Godwin U., Ichoron, Nahandoo, Siheri, Weam, Watson, David G., Igoli, John O., De Koning, Harry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663965/
https://www.ncbi.nlm.nih.gov/pubmed/33167520
http://dx.doi.org/10.3390/molecules25215155
_version_ 1783609748708392960
author Ebiloma, Godwin U.
Ichoron, Nahandoo
Siheri, Weam
Watson, David G.
Igoli, John O.
De Koning, Harry P.
author_facet Ebiloma, Godwin U.
Ichoron, Nahandoo
Siheri, Weam
Watson, David G.
Igoli, John O.
De Koning, Harry P.
author_sort Ebiloma, Godwin U.
collection PubMed
description The kinetoplastids are protozoa characterized by the presence of a distinctive organelle, called the kinetoplast, which contains a large amount of DNA (kinetoplast DNA (kDNA)) inside their single mitochondrion. Kinetoplastids of medical and veterinary importance include Trypanosoma spp. (the causative agents of human and animal African Trypanosomiasis and of Chagas disease) and Leishmania spp. (the causative agents of the various forms of leishmaniasis). These neglected diseases affect millions of people across the globe, but drug treatment is hampered by the challenges of toxicity and drug resistance, among others. Propolis (a natural product made by bees) and compounds isolated from it are now being investigated as novel treatments of kinetoplastid infections. The anti-kinetoplastid efficacy of propolis is probably a consequence of its reported activity against kinetoplastid parasites of bees. This article presents a review of the reported anti-kinetoplastid potential of propolis, highlighting its anti-kinetoplastid activity in vitro and in vivo regardless of geographical origin. The mode of action of propolis depends on the organism it is acting on and includes growth inhibition, immunomodulation, macrophage activation, perturbation of the cell membrane architecture, phospholipid disturbances, and mitochondrial targets. This gives ample scope for further investigations toward the rational development of sustainable anti-kinetoplastid drugs.
format Online
Article
Text
id pubmed-7663965
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76639652020-11-14 The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets Ebiloma, Godwin U. Ichoron, Nahandoo Siheri, Weam Watson, David G. Igoli, John O. De Koning, Harry P. Molecules Review The kinetoplastids are protozoa characterized by the presence of a distinctive organelle, called the kinetoplast, which contains a large amount of DNA (kinetoplast DNA (kDNA)) inside their single mitochondrion. Kinetoplastids of medical and veterinary importance include Trypanosoma spp. (the causative agents of human and animal African Trypanosomiasis and of Chagas disease) and Leishmania spp. (the causative agents of the various forms of leishmaniasis). These neglected diseases affect millions of people across the globe, but drug treatment is hampered by the challenges of toxicity and drug resistance, among others. Propolis (a natural product made by bees) and compounds isolated from it are now being investigated as novel treatments of kinetoplastid infections. The anti-kinetoplastid efficacy of propolis is probably a consequence of its reported activity against kinetoplastid parasites of bees. This article presents a review of the reported anti-kinetoplastid potential of propolis, highlighting its anti-kinetoplastid activity in vitro and in vivo regardless of geographical origin. The mode of action of propolis depends on the organism it is acting on and includes growth inhibition, immunomodulation, macrophage activation, perturbation of the cell membrane architecture, phospholipid disturbances, and mitochondrial targets. This gives ample scope for further investigations toward the rational development of sustainable anti-kinetoplastid drugs. MDPI 2020-11-05 /pmc/articles/PMC7663965/ /pubmed/33167520 http://dx.doi.org/10.3390/molecules25215155 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ebiloma, Godwin U.
Ichoron, Nahandoo
Siheri, Weam
Watson, David G.
Igoli, John O.
De Koning, Harry P.
The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets
title The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets
title_full The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets
title_fullStr The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets
title_full_unstemmed The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets
title_short The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets
title_sort strong anti-kinetoplastid properties of bee propolis: composition and identification of the active agents and their biochemical targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663965/
https://www.ncbi.nlm.nih.gov/pubmed/33167520
http://dx.doi.org/10.3390/molecules25215155
work_keys_str_mv AT ebilomagodwinu thestrongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT ichoronnahandoo thestrongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT siheriweam thestrongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT watsondavidg thestrongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT igolijohno thestrongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT dekoningharryp thestrongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT ebilomagodwinu strongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT ichoronnahandoo strongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT siheriweam strongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT watsondavidg strongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT igolijohno strongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets
AT dekoningharryp strongantikinetoplastidpropertiesofbeepropoliscompositionandidentificationoftheactiveagentsandtheirbiochemicaltargets