Cargando…

Anti-neoplastic Effect of Ginkgolide C through Modulating c-Met Phosphorylation in Hepatocellular Carcinoma Cells

Ginkgolide C (GGC) derived from Ginkgo biloba, has been reported to exhibit various biological functions. However, the anti-neoplastic effect of GGC and its mechanisms in liver cancer have not been studied previously. Hepatocyte growth factor (HGF)/c-mesenchymal–epithelial transition receptor (c-Met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Min Hee, Baek, Seung Ho, Um, Jae-Young, Ahn, Kwang Seok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664003/ https://www.ncbi.nlm.nih.gov/pubmed/33167504 http://dx.doi.org/10.3390/ijms21218303

Ejemplares similares

Procaine Abrogates the Epithelial-Mesenchymal Transition Process through Modulating c-Met Phosphorylation in Hepatocellular Carcinoma
por: Yang, Min Hee, et al.
Publicado: (2022)

Albendazole Exhibits Anti-Neoplastic Actions against Gastric Cancer Cells by Affecting STAT3 and STAT5 Activation by Pleiotropic Mechanism(s)
por: Yang, Min Hee, et al.
Publicado: (2021)

Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model
por: Yang, Min Hee, et al.
Publicado: (2023)

Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities
por: Wang, Ying, et al.
Publicado: (2016)

Transformation of multi-component ginkgolide into ginkgolide B by Coprinus comatus
por: Ding, HongXue, et al.
Publicado: (2015)

Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells
por: Hwang, Sun Tae, et al.
Publicado: (2020)

Biosynthesis pathways of ginkgolides
por: Zeng, Zihan, et al.
Publicado: (2013)

Neuroregulatory role of ginkgolides
por: Gachowska, Martyna, et al.
Publicado: (2021)

Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades
por: Lee, Hanwool, et al.
Publicado: (2017)

New Phosphorylation Sites of Rad51 by c-Met Modulates Presynaptic Filament Stability
por: Chabot, Thomas, et al.
Publicado: (2019)

Ginkgolide B Modulates BDNF Expression in Acute Ischemic Stroke
por: Wei, Hu, et al.
Publicado: (2017)

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen-glucose deprivation
por: Yu, Wen-Bo, et al.
Publicado: (2018)

Euphorbiasteroid Induces Apoptosis as Well as Autophagy through Modulating SHP-1/STAT3 Pathway in Hepatocellular Carcinoma Cells
por: Kim, Na Young, et al.
Publicado: (2023)

Mixed antagonistic effects of the ginkgolides at recombinant human ρ(1) GABA(C) receptors
por: Huang, Shelley H., et al.
Publicado: (2012)

Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs
por: Zhao, Jie, et al.
Publicado: (2015)

Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors
por: Du, Yi, et al.
Publicado: (2016)

Targeting the HGF-cMET Axis in Hepatocellular Carcinoma
por: Venepalli, Neeta K., et al.
Publicado: (2013)

Clinical Development of c-MET Inhibition in Hepatocellular Carcinoma
por: Lee, Joycelyn J. X., et al.
Publicado: (2015)

The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
por: Wang, Haiyu, et al.
Publicado: (2020)

Phosphorylation State-Dependent High Throughput Screening of the c-Met Kinase
por: Behshad, Elham, et al.
Publicado: (2010)

Ginkgolide C reduced oleic acid-induced lipid accumulation in HepG2 cells
por: Huang, Wen-Chung, et al.
Publicado: (2018)

New Preclinical Development of a c-Met Inhibitor and Its Combined Anti-Tumor Effect in c-Met-Amplified NSCLC
por: Kim, Nam Ah, et al.
Publicado: (2020)

Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway
por: Liou, Chian-Jiun, et al.
Publicado: (2015)

An autophagy-inducing stapled peptide promotes c-MET degradation and overrides adaptive resistance to sorafenib in c-MET(+) hepatocellular carcinoma
por: Gao, Shan, et al.
Publicado: (2022)

Optimizing the Formulation for Ginkgolide B Solid Dispersion
por: Wu, Xiao, et al.
Publicado: (2018)

Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation
por: Oppermann, Henry, et al.
Publicado: (2016)

Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
por: Baek, Seung Ho, et al.
Publicado: (2017)

The Association between EGFR and cMET Expression and Phosphorylation and Its Prognostic Implication in Patients with Breast Cancer
por: Chae, Young Kwang, et al.
Publicado: (2016)

A Human Anti-c-Met Fab Fragment Conjugated with Doxorubicin as Targeted Chemotherapy for Hepatocellular Carcinoma
por: Chen, Ximin, et al.
Publicado: (2013)

Dramatic Response to Cabozantinib in a Patient with Refractory Hepatocellular Carcinoma with c-MET Amplification
por: Sang, Yun Beom, et al.
Publicado: (2023)

ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma
por: Ma, Xiao-Lu, et al.
Publicado: (2023)

Corrigendum to “Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway”
por: Liou, Chian-Jiun, et al.
Publicado: (2017)

Foretinib Enhances the Radiosensitivity in Esophageal Squamous Cell Carcinoma by Inhibiting Phosphorylation of c-Met
por: Chen, Guang-Zong, et al.
Publicado: (2017)

Epigenetic Upregulation of HGF and c-Met Drives Metastasis in Hepatocellular Carcinoma
por: Ogunwobi, Olorunseun O., et al.
Publicado: (2013)

Recent developments of c‐Met as a therapeutic target in hepatocellular carcinoma
por: Bouattour, Mohamed, et al.
Publicado: (2018)

The role of c-MET inhibitors in advanced hepatocellular carcinoma: now and future
por: Woo, Hyun Young, et al.
Publicado: (2020)

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis
por: Yu, Yan, et al.
Publicado: (2021)

High-Affinity Human Anti-c-Met IgG Conjugated to Oxaliplatin as Targeted Chemotherapy for Hepatocellular Carcinoma
por: Ma, Yilan, et al.
Publicado: (2019)

Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma
por: Yin, Yanxin, et al.
Publicado: (2019)

Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells
por: Park, Chi Hoon, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mmqdikj55unav2kngeqci30gup