Cargando…
Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with an increased cardiovascular risk related at least in part to a more vulnerable plaque phenotype. However, patients with T2DM exhibit also an increased risk following percutaneous coronary intervention (PCI). It is unknown if plaque vulne...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664108/ https://www.ncbi.nlm.nih.gov/pubmed/33183273 http://dx.doi.org/10.1186/s12933-020-01168-4 |
_version_ | 1783609778700812288 |
---|---|
author | Dettori, Rosalia Milzi, Andrea Burgmaier, Kathrin Almalla, Mohammad Hellmich, Martin Marx, Nikolaus Reith, Sebastian Burgmaier, Mathias |
author_facet | Dettori, Rosalia Milzi, Andrea Burgmaier, Kathrin Almalla, Mohammad Hellmich, Martin Marx, Nikolaus Reith, Sebastian Burgmaier, Mathias |
author_sort | Dettori, Rosalia |
collection | PubMed |
description | BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with an increased cardiovascular risk related at least in part to a more vulnerable plaque phenotype. However, patients with T2DM exhibit also an increased risk following percutaneous coronary intervention (PCI). It is unknown if plaque vulnerability of a treated lesion influences cardiovascular outcomes in patients with T2DM. In this study, we aimed to assess the association of plaque morphology as determined by optical coherence tomography (OCT) with cardiovascular outcome following PCI in high-risk patients with T2DM. METHODS: 81 patients with T2DM and OCT-guided PCI were recruited. Pre-interventional OCT and systematic follow-up of median 66.0 (IQR = 8.0) months were performed. RESULTS: During follow-up, 24 patients (29.6%) died. The clinical parameters age (HR 1.16 per year, 95% CI 1.07–1.26, p < 0.001), diabetic polyneuropathy (HR 3.58, 95% CI 1.44–8.93, p = 0.006) and insulin therapy (HR 3.25, 95% CI 1.21–8.70, p = 0.019) predicted mortality in T2DM patients independently. Among OCT parameters only calcium-volume-index (HR 1.71 per 1000°*mm, 95% CI 1.21–2.41, p = 0.002) and lesion length (HR 1.93 per 10 mm, 95% CI 1.02–3.67, p = 0.044) as parameters describing atherosclerosis extent were significant independent predictors of mortality. However, classical features of plaque vulnerability, such as thickness of the fibrous cap, the extent of the necrotic lipid core and the presence of macrophages had no significant predictive value (all p = ns). CONCLUSION: Clinical parameters including those describing diabetes severity as well as OCT-parameters characterizing atherosclerotic extent but not classical features of plaque vulnerability predict mortality in T2DM patients following PCI. These data suggest that PCI may provide effective plaque sealing resulting in limited importance of local target lesion vulnerability for future cardiovascular events in high-risk patients with T2DM. |
format | Online Article Text |
id | pubmed-7664108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76641082020-11-13 Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study Dettori, Rosalia Milzi, Andrea Burgmaier, Kathrin Almalla, Mohammad Hellmich, Martin Marx, Nikolaus Reith, Sebastian Burgmaier, Mathias Cardiovasc Diabetol Original Investigation BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with an increased cardiovascular risk related at least in part to a more vulnerable plaque phenotype. However, patients with T2DM exhibit also an increased risk following percutaneous coronary intervention (PCI). It is unknown if plaque vulnerability of a treated lesion influences cardiovascular outcomes in patients with T2DM. In this study, we aimed to assess the association of plaque morphology as determined by optical coherence tomography (OCT) with cardiovascular outcome following PCI in high-risk patients with T2DM. METHODS: 81 patients with T2DM and OCT-guided PCI were recruited. Pre-interventional OCT and systematic follow-up of median 66.0 (IQR = 8.0) months were performed. RESULTS: During follow-up, 24 patients (29.6%) died. The clinical parameters age (HR 1.16 per year, 95% CI 1.07–1.26, p < 0.001), diabetic polyneuropathy (HR 3.58, 95% CI 1.44–8.93, p = 0.006) and insulin therapy (HR 3.25, 95% CI 1.21–8.70, p = 0.019) predicted mortality in T2DM patients independently. Among OCT parameters only calcium-volume-index (HR 1.71 per 1000°*mm, 95% CI 1.21–2.41, p = 0.002) and lesion length (HR 1.93 per 10 mm, 95% CI 1.02–3.67, p = 0.044) as parameters describing atherosclerosis extent were significant independent predictors of mortality. However, classical features of plaque vulnerability, such as thickness of the fibrous cap, the extent of the necrotic lipid core and the presence of macrophages had no significant predictive value (all p = ns). CONCLUSION: Clinical parameters including those describing diabetes severity as well as OCT-parameters characterizing atherosclerotic extent but not classical features of plaque vulnerability predict mortality in T2DM patients following PCI. These data suggest that PCI may provide effective plaque sealing resulting in limited importance of local target lesion vulnerability for future cardiovascular events in high-risk patients with T2DM. BioMed Central 2020-11-12 /pmc/articles/PMC7664108/ /pubmed/33183273 http://dx.doi.org/10.1186/s12933-020-01168-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Original Investigation Dettori, Rosalia Milzi, Andrea Burgmaier, Kathrin Almalla, Mohammad Hellmich, Martin Marx, Nikolaus Reith, Sebastian Burgmaier, Mathias Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study |
title | Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study |
title_full | Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study |
title_fullStr | Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study |
title_full_unstemmed | Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study |
title_short | Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study |
title_sort | prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664108/ https://www.ncbi.nlm.nih.gov/pubmed/33183273 http://dx.doi.org/10.1186/s12933-020-01168-4 |
work_keys_str_mv | AT dettorirosalia prognosticirrelevanceofplaquevulnerabilityfollowingplaquesealinginhighriskpatientswithtype2diabetesanopticalcoherencetomographystudy AT milziandrea prognosticirrelevanceofplaquevulnerabilityfollowingplaquesealinginhighriskpatientswithtype2diabetesanopticalcoherencetomographystudy AT burgmaierkathrin prognosticirrelevanceofplaquevulnerabilityfollowingplaquesealinginhighriskpatientswithtype2diabetesanopticalcoherencetomographystudy AT almallamohammad prognosticirrelevanceofplaquevulnerabilityfollowingplaquesealinginhighriskpatientswithtype2diabetesanopticalcoherencetomographystudy AT hellmichmartin prognosticirrelevanceofplaquevulnerabilityfollowingplaquesealinginhighriskpatientswithtype2diabetesanopticalcoherencetomographystudy AT marxnikolaus prognosticirrelevanceofplaquevulnerabilityfollowingplaquesealinginhighriskpatientswithtype2diabetesanopticalcoherencetomographystudy AT reithsebastian prognosticirrelevanceofplaquevulnerabilityfollowingplaquesealinginhighriskpatientswithtype2diabetesanopticalcoherencetomographystudy AT burgmaiermathias prognosticirrelevanceofplaquevulnerabilityfollowingplaquesealinginhighriskpatientswithtype2diabetesanopticalcoherencetomographystudy |