CRIPTO antagonist ALK4(L75A)-Fc inhibits breast cancer cell plasticity and adaptation to stress

BACKGROUND: CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4(L75A)-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesting it may similarly inhibit CRIPTO-dependent pl...

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Detalles Bibliográficos
Autores principales: Balcioglu, Ozlen, Heinz, Richard E., Freeman, David W., Gates, Brooke L., Hagos, Berhane M., Booker, Evan, Mirzaei Mehrabad, Elnaz, Diesen, Hyrum T., Bhakta, Kishan, Ranganathan, Supraja, Kachi, Masami, Leblanc, Mathias, Gray, Peter C., Spike, Benjamin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664111/
https://www.ncbi.nlm.nih.gov/pubmed/33187540
http://dx.doi.org/10.1186/s13058-020-01361-z

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