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Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study

OBJECTIVE: To evaluate whether multiple sessions of transcranial direct current stimulation (tDCS) applied to the primary motor (M1) cortex paired with aerobic exercise can improve walking functions in multiple sclerosis (MS). METHODS: MS participants were recruited for a double‐blind, parallel‐arm,...

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Autores principales: Pilloni, Giuseppina, Choi, Claire, Shaw, Michael T, Coghe, Giancarlo, Krupp, Lauren, Moffat, Marilyn, Cocco, Eleonora, Pau, Massimiliano, Charvet, Leigh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664269/
https://www.ncbi.nlm.nih.gov/pubmed/33080122
http://dx.doi.org/10.1002/acn3.51224
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author Pilloni, Giuseppina
Choi, Claire
Shaw, Michael T
Coghe, Giancarlo
Krupp, Lauren
Moffat, Marilyn
Cocco, Eleonora
Pau, Massimiliano
Charvet, Leigh
author_facet Pilloni, Giuseppina
Choi, Claire
Shaw, Michael T
Coghe, Giancarlo
Krupp, Lauren
Moffat, Marilyn
Cocco, Eleonora
Pau, Massimiliano
Charvet, Leigh
author_sort Pilloni, Giuseppina
collection PubMed
description OBJECTIVE: To evaluate whether multiple sessions of transcranial direct current stimulation (tDCS) applied to the primary motor (M1) cortex paired with aerobic exercise can improve walking functions in multiple sclerosis (MS). METHODS: MS participants were recruited for a double‐blind, parallel‐arm, randomized, sham‐controlled trial and assigned to 10 sessions (5 d/wk for 2 weeks) of either active or sham tDCS paired with unloaded cycling for 20 minutes. Stimulation was administered over the left M1 cortex (2.5 mA; anode over C3/cathode over FP2). Gait spatiotemporal parameters were assessed using a wearable inertial sensor (10‐meter and 2‐minute walking tests). Measurements were collected at baseline, end of tDCS intervention, and 4‐week postintervention to test for duration of any benefits. RESULTS: A total of 15 participants completed the study, nine in the active and six in the sham condition. The active and sham groups were matched according to gender (50% vs. 40% female), neurologic disability (median EDSS 5.5 vs. 5), and age (mean 52.1 ± 12.9 vs. 53.7 ± 9.8 years). The active group had a significantly greater increase in gait speed (0.87 vs. 1.20 m/s, p < 0.001) and distance covered during the 2‐minute walking test (118.53 vs. 133.06 m, p < 0.001) at intervention end compared to baseline. At 4‐week follow‐up, these improvements were maintained (baseline vs. follow‐up: gait speed 0.87 vs. 1.18 m/s, p < 0.001; distance traveled 118.53 vs. 143.82 m, p < 0.001). INTERPRETATION: Multiple sessions of tDCS paired with aerobic exercise lead to cumulative and persisting improvements in walking and endurance in patients with MS.
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spelling pubmed-76642692020-11-17 Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study Pilloni, Giuseppina Choi, Claire Shaw, Michael T Coghe, Giancarlo Krupp, Lauren Moffat, Marilyn Cocco, Eleonora Pau, Massimiliano Charvet, Leigh Ann Clin Transl Neurol Research Articles OBJECTIVE: To evaluate whether multiple sessions of transcranial direct current stimulation (tDCS) applied to the primary motor (M1) cortex paired with aerobic exercise can improve walking functions in multiple sclerosis (MS). METHODS: MS participants were recruited for a double‐blind, parallel‐arm, randomized, sham‐controlled trial and assigned to 10 sessions (5 d/wk for 2 weeks) of either active or sham tDCS paired with unloaded cycling for 20 minutes. Stimulation was administered over the left M1 cortex (2.5 mA; anode over C3/cathode over FP2). Gait spatiotemporal parameters were assessed using a wearable inertial sensor (10‐meter and 2‐minute walking tests). Measurements were collected at baseline, end of tDCS intervention, and 4‐week postintervention to test for duration of any benefits. RESULTS: A total of 15 participants completed the study, nine in the active and six in the sham condition. The active and sham groups were matched according to gender (50% vs. 40% female), neurologic disability (median EDSS 5.5 vs. 5), and age (mean 52.1 ± 12.9 vs. 53.7 ± 9.8 years). The active group had a significantly greater increase in gait speed (0.87 vs. 1.20 m/s, p < 0.001) and distance covered during the 2‐minute walking test (118.53 vs. 133.06 m, p < 0.001) at intervention end compared to baseline. At 4‐week follow‐up, these improvements were maintained (baseline vs. follow‐up: gait speed 0.87 vs. 1.18 m/s, p < 0.001; distance traveled 118.53 vs. 143.82 m, p < 0.001). INTERPRETATION: Multiple sessions of tDCS paired with aerobic exercise lead to cumulative and persisting improvements in walking and endurance in patients with MS. John Wiley and Sons Inc. 2020-10-20 /pmc/articles/PMC7664269/ /pubmed/33080122 http://dx.doi.org/10.1002/acn3.51224 Text en © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Pilloni, Giuseppina
Choi, Claire
Shaw, Michael T
Coghe, Giancarlo
Krupp, Lauren
Moffat, Marilyn
Cocco, Eleonora
Pau, Massimiliano
Charvet, Leigh
Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study
title Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study
title_full Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study
title_fullStr Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study
title_full_unstemmed Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study
title_short Walking in multiple sclerosis improves with tDCS: a randomized, double‐blind, sham‐controlled study
title_sort walking in multiple sclerosis improves with tdcs: a randomized, double‐blind, sham‐controlled study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664269/
https://www.ncbi.nlm.nih.gov/pubmed/33080122
http://dx.doi.org/10.1002/acn3.51224
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